一、課程說明(Course Description)
<br>This is an advanced level, paper discussion based course. It is designed for graduate students who are interested in studying mitochondrial related topics. The course aims to provide students with the advanced knowledge of genetics and pathophysiology of mitochondria. The up-to-date research topics and literature in this field will also be covered. Students who have knowledge of cell biology, molecular biology and genetics are preferred.
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<br>二、指定用書(Text Books)
<br>The assigned readings will include the latest literature and prepared handouts. These references will be announced or given one week before the class.
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<br>三、參考書籍(References)
<br>The latest research papers focused on mitochondrial studies
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<br>四、教學方式(Teaching Method)
<br>The first fourteen weeks of this course will focus on advanced topics on mitochondrial studies using journal discussion format. The following five weeks of this course will be student’s presentation on selected topics.
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<br>五、教學進度(Syllabus)
<br>Week        Topics 
<br>1.	Introduction
<br>2.	Mitochondrial morphology and dynamics
<br>3.	Pathophysiology of mitochondrial electric transport chain
<br>4.	The effects of steroid hormones on the transcription of genes encoding enzymes of oxidative phosphorylation
<br>5.	Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis
<br>6.	Oxidative stress, environmental toxins and mitochondrial diseases
<br>7.	Methods to detect mitochondrial function
<br>8.	Mitochondria-mediated apoptosis in neurodegenerative diseases
<br>9.	Human complex I defects in neurodegenerative diseases
<br>10.	Cybrids as cell models for studies on mitochondrial diseases
<br>11.	Mitochondria and apoptosis in cancer 
<br>12.	Mitochondria and apoptosis in aging
<br>13.	Mouse models of mitochondrial diseases
<br>14.	Student’s  presentation on selected topics I
<br>15.	Student’s  presentation on selected topics II
<br>16.	Student’s  presentation on selected topics III
<br>17.	Student’s  presentation on selected topics IV
<br>18.	Final discussion
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<br>六、成績考核(Evaluation)
<br>Your grade will be based on your performance and participation in the class (50%), and one presentation on selected topics for this course (50%).
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<br>七、可連結之網頁位址
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<br>http://life.nthu.edu.tw/~labkmc/
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