一、 課程說明
Familiarize students to genomic methods.
Encourage students to think on genomic scale.
Excite students about hottest areas of biology.
Demystify modern methods and concepts.
Introduce necessary jargon but keep it to a minimum.
Foster experimental design in genomics.
Discover basic biology in the context of applied research.
Use case study method to extract concepts.

二、 指定用書
Discovering Genomics, Proteomics and Bioinformatics 2nd edition
- by A. Malcolm Campbell and Laurie J. Heyer. (ISBN 0-8053-4722-4; published by Cold Spring Harbor Laboratory Press and Benjamin Cummings: 28 February, 2006)


三、 參考書籍
Structural and Evolutionary Genomics

四、 教學方式
投影片講解,討論

五、 課程大綱
1.Human Genome Project: the moving force.
2.HapMap Project: from genome sequence to variation.
3.Current genomic technology.
4.Analysis of microarray data.
5.Proteomics and biomarker discovery.
6.Introduction to systems biology.
7.Review session for the first block
8.Cancer genomics (I)
9.Cancer genomics (II)
10.Pharmacogenomcis (I)
11.Pharmcogenomics (II)
12.Microbial genomics (I)
13.Microbial genomics (II)
14.Environmental genomics
15.Review session for the second block.
16.Final examination

六、 教學進度

# M/D/Y Topics -- Lecturer -- Textbook Chapter
1 9/10/07 Introduction and organization, model systems for genome biology -- Yuh -- Chapter 1-2, 2-3, 3-1, 3-2
2 9/17/07 Human Genome Project: the moving force. -- Tsai --Chapter 1-1
3 10/1/07 HapMap Project: from genome sequence to variation. -- Tsai --Chapter 4
4 10/8/07 Current genomic technology. -- Tsai -- Chapter 2-1
5 10/15/07 Analysis of microarray data. -- Chuang -- Chapter 6
6 10/22/07 Proteomics and biomarker discovery. -- Chuang -- Chapter 8
7 10/29/07 Introduction to systems biology and genomic circuits in single genes -- Yuh -- Chapter 9, 10
8 11/5/07 Integrated genomic circuits and modeling whole-genome circuits -- Yuh -- Chapter 11, 12
9 11/12/07 Review session for the first block -- Yuh
10 11/19/07 Midterm examination -- Chuang
11 11/26/07 Cancer genomics -- Tsai -- Chapter 7
12 12/3/07 Pharmacogenomcis -- Tsai
13 12/10/07 Microbial genomics -- Tsai -- Chapter 2-2
14 12/17/07 Environmental genomics -- Tsai
15 12/24/07 Human population and evolution -- Tsai
16 12/31/07 Review session for the second block -- Tsai
17 1/7/08 Final examination --Chuang



七、 成績考核
出席率10 %,期中考30%,報告15 %,期末考45%