一、課程說明(Course Description):
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<br>This course is designed for students who are interested in studying mitochondrial genome and related defects. The course aims to provide students with the basic knowledge of the mitochondrial genetics and the pathology of related diseases. The up-to-date research topics and literature in this field will also be covered. Students who have knowledge of molecular biology and genetics are preferred.
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<br>二、指定用書(Text Books)
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<br>The assigned readings will include the latest literature and prepared handouts. These references will be announced or given one week before the class
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<br>三、參考書籍(References)
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<br>四、教學方式(Teaching Method)
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<br>The first ten weeks of this course will focus on basic knowledge delivery of mitochondrial genetics and related diseases. The following eight weeks of this course will be paper discussion which will center on the latest development and findings in pathogenesis of mitochondrial diseases.
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<br>五、教學進度(Syllabus)
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<br>Date        Topics 
<br>Week 1   Introduction 
<br>Week 2    Mitochondrial genome and genetics 
<br>Week 3    Mitochondrial biology 
<br>Week 4    Nuclear genes and oxidative phosphorylation (OXPHOS)
<br>Week 5    Mitochondrial diseases
<br>Week 6    Genetic defects in the OXPHOS system
<br>Week 7    Somatic mtDNA mutations in aging and cancer 
<br>Week 8    Oxidative stress, environmental toxins and complex I
<br>Week 9    Human complex I defects in neurodegenerative diseases
<br>Week 10   Mouse models of mitochondrial diseases
<br>Week 11  Examination
<br>Week 12   Paper discussion I
<br>Week 13   Paper discussion II
<br>Week 14   Paper discussion III
<br>Week 15   Paper discussion IV
<br>Week 16   Paper discussion V 
<br>Week 17   Paper discussion VI 
<br>Week 18  Final discussion 
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<br>六、成績考核(Evaluation)
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<br>Your grade will be based on your performance and participation in the class (25%), one mid-term examination (50%) and one final term paper for this course (25%).
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<br>七、可連結之網頁位址