一、課程說明(Course Description)
<br>   This is a course of intermediate level, which is intended to give students a deeper overview of Bioenergetics and Oxidative Phosphorylation System. Mammalian and bacterial aspects of these areas will be specifically emphasized. 
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<br>二、指定用書(Text Books)
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<br>三、參考書籍(References)
<br>The latest research papers focused on Bioenergetics and OXPHOS studies
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<br>四、教學方式(Teaching Method)
<br>The class will be divided into two parts: the first 16 weeks will be lectures given by the instructor and the following 2 weeks will be seminars presented by students in the class.
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<br>五、教學進度(Syllabus)
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<br>Week     Topics
<br>1.    Brief orientation
<br>2.    Introduction to biochemical energetics
<br>3.    Electron-transfer reactions in mitochondria
<br>4.    Structure and function of complex I: NADH dehydrogenase (1)
<br>5.    Structure and function of complex I: NADH dehydrogenase (2)
<br>6.    Structure and function of complex II: succinate dehydrogenase 
<br>7.    Structure and function of complex III: cytochrome c reductase 
<br>8.    Structure and function of complex IV: cytochrome c reductase 
<br>9.    Mid-term Examination
<br>10.   ATP synthesis by complex V: ATP synthase (1)
<br>11.   ATP synthesis by complex V: ATP synthase (2)
<br>12.   Mitchondrial membrane transport
<br>13.   Regulation of oxidative phosphorylation
<br>14.   Versatility of the mitochondrial protein import machinery
<br>15.   The role of mitochondria in apoptosis, oxidative stress and aging
<br>16.   Final Examination
<br>17.   Student presentation (1)
<br>18.   Student presentation (2)
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<br>六、成績考核(Evaluation)
<br>70%  one in-class written examination
<br>20%  seminar presentation
<br>10%  participation (attendance, discussion and question asking)
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<br>七、可連結之網頁位址
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