一、課程說明(Course Description)
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<br>Translational medicine can be defined as "bench-to-bedside" research wherein a basic laboratory discovery becomes applicable to the diagnosis, treatment or prevention of a specific disease. In this year, we will foucs on the applicaiton of using transgenic zebrafish as a human disease model. We will discuss guidelines for designing and conducting a translational study and analyzing and reporting results and discusses key ethical and regulatory issues. We will also discuss selected successful examples and cover the basic sciences behind them.
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<br> 二、參考用書(Reference Books)
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<br>"Translationl and experimental clinical research" 
<br>By Daniel P. Schuster and William J. Powers 
<br>Lippincott Williams & Willkins
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<br> 三、參考期刊(References)
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<br>Journal of Translational Medicine
<br>http://www.translational-medicine.com/
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<br> 四、教學方式(Teaching Method)
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<br>Lectures; Project; Group Presentation and Discussion
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<br> 五、暫訂教學進度(Syllabus)
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<br>Introduction 
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<br>Section 1: Planning and Designing Translational Research
<br>1.	Defining the research question 
<br>2.	Experimental study designs 
<br>3.	Database development 
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<br>Section 2: Modern Techniques of translational research
<br>1.	Genomics: gene expression profiling, SNP, molecular cloning 
<br>2.	Proteomics 
<br>3.	Metabolomics and Cellomics 
<br>4.	Cell and tissue imaging 
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<br>Midterm Evaluation (Group Project Discussion and Presentation) 
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<br>Section 3: Special topics
<br>1.	“Small” clinical research 
<br>2.	Pharmacokinetics and pharmacodynamics 
<br>3.	Gene therapy and pharmacogenomic studies 
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<br>Section 4: Analyzing and reporting results
<br>1.	Hypothesis testing 
<br>2.	Data analysis 
<br>3.	Presentation Data 
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<br>Final Evaluation (Term Paper) 
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<br> 六、成績考核(Evaluation)
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<br>1. Quiz (2) 10% each; and Exam (1) 20%
<br>2. Group project/presentation (1) 30%
<br>3. Term paper (1) 30%
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<br> 七、可連結之網頁位址
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<br>TBA; E-Learning system
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