1. Course Description:
<br>The course of Epigenetics and epigenome is focus on the study of stable genetic modifications that result in changes in gene expression and function without a corresponding alteration in DNA sequence. The epigenome is refereed to a catalog of the epigenetic modifications that occur in the genome. Many diseases have associated with epigenetics changes. New methods to detect the modifications and better understandings of factors that drive these changes have made progress in this field. Thus, this course is designed to introduce the concepts and the new developments of epigenetics to students. Latest papers on fundamental aspects of epigenetics will be discussed along with the corresponding lectures.
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<br>2. Text Books: N/A
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<br>3. References: 
<br>Epigenetics, Cold Spring Harbor Laboratory Press, 2007, ISBN  978-087969875-1
<br>Related papers in the latest journals such as Nature, Science, and Cell.
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<br>4. Teaching Method:
<br>English lectures with paper discussions
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<br>5. Syllabus:
<br>Week 1: Introduction
<br>Week 2: What is Epigenetics
<br>Week 3: Euchromatin and Heterochromatin
<br>Week 4: Silent Chromatin
<br>Week 5: Position Effects
<br>Week 6: Nucleosome and chromatin assembly 
<br>Week 7: Chromatin dynamics
<br>Week 8: Mid-term-
<br>Week 9: Histone modification code
<br>Week 10: Transcription activation
<br>Week 11: Gene suppression
<br>Week 12: Cohesion and gene repression
<br>Week 13: RNAi and gene regulation
<br>Week 14: Epigenome
<br>Week 15: Epigenetics and diseases
<br>Week 16: Final Exam
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<br>6. Evaluation:
<br>40% - Mid-term Exam
<br>40% - Final Exam
<br>10% - discussion in the classes
<br>10% - attendance.
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<br>7. Hyperlink:
<br>http://moodle.nthu.edu.tw/