一、課程說明(Course Description)
癌病訊號調控學在課程的安排上,將延續上個學期的課程,以實例介紹訊號調控在各種癌症疾病系統,所扮演的重要性與系統性,以期修課同學能從基礎理論到臨床應用,對癌病訊號調控有一整體性的瞭解。
二、指定用書(Text Books)
癌症相關期刊
三、參考書籍(References)
Joyce, J.A. & Pollard, J.W. Microenvironmental regulation of metastasis. Nat Rev Cancer 9, 239-252 (2009).
Mishra, P.J., Glod, J.W. & Banerjee, D. Mesenchymal stem cells: flip side of the coin. Cancer Res 69, 1255-1258 (2009).
Ostrand-Rosenberg, S. & Sinha, P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182, 4499-4506 (2009).
Psaila, B. & Lyden, D. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 9, 285-293 (2009).
Boman, B.M. & Wicha, M.S. Cancer stem cells: a step toward the cure. J Clin Oncol 26, 2795-2799 (2008).
Yu, H., Kortylewski, M. & Pardoll, D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7, 41-51 (2007).
Bissell, M.J. & Radisky, D. Putting tumours in context. Nat Rev Cancer 1, 46-54 (2001).
四、教學方式(Teaching Method)
採用最新文獻與過去經典著作,由上學期課程中所談癌症亟需解決的問題選擇原始論文深入了解,癌症鎖定乳癌、肺癌、肝癌、胰臟癌、胃癌及大腸直腸癌,由同學先做報告,再由教授做一個系統性講解及分析。
五、教學進度(Syllabus)
六、成績考核(Evaluation)
1.上課出席情況
2.課堂表現
3.作業
七、可連結之網頁位址
講義在課堂上適時分發