一、課程說明(Course Description)
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<br>Engineers meet Biologists: Cytoarchitecture, Cell crawling and Cell mechanics offers a course to explain 
<br>the mechanical properties of the cytoskeleton for graduate students in the general field of cell biology and 
<br>for engineers required to consider added dimensions to their work. In the first part of this course, we will 
<br>focus on the architecture of the biological cell's internal structure formed by an interconnected network of 
<br>the cytoskelon, including microtubules, microfilaments and intermediate filaments. In the second part, 
<br>courses will be centered on topics such as underlying physical principles behind cytoskeletal structures, 
<br>and mechanical foundation for molecular motors.
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<br>二、指定用書(Text Books)
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<br>No
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<br>三、參考書籍(References)
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<br>Mechanics of the Cell by David Boal, Cambridge University Press (2001).
<br>Mechanics of Motor Proteins and the Cytoskeleton by Jonathon Howard, Sinauer Associates Inc.,U.S.; New 
<br>edition (2005). 
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<br>四、教學方式(Teaching Method)
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<br>This course is intended to offer students with knowledge in the field of cytoskeletal research with 
<br>particular focus on the celullar fiber system, cellular movement mechanisms, mechanotransduction and 
<br>biophysical properties of the cytoskeleton. In addititon to assigned textbook, the teaching contents will 
<br>come from most recent review articles, which will provide students with the most up-to-date knowledge 
<br>and advance in the cytoarchitecture, cell crawling and cell mechanics. We also invite lecturers from 
<br>Department of Biomedical Engineering and environmental Science and from National Chiao-Tung 
<br>University to share their expertise in this field. This course will be offered in  English. 
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<br>五、教學進度(Syllabus)
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<br> 共15周, 每周 2 小時
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<br>1. Introduction of the cytoskeleton
<br>2. Microtubule and its associated proteins
<br>3. Actin-containing microfilaments
<br>4. Intermediate filament cytoskeleton
<br>5. The microtubules and neurodegenerative disease
<br>6. The cytoskeleton and cell mobility
<br>7. Cytoskeletal defects and human diseases 
<br>8. Kinesins, their mechanical properties and MEMS 
<br>9. Myosins, Dynein and an the problems of trafficking
<br>10. Biological and non-biological nanomachines
<br>11. Cell mechanics I
<br>12. Cell mechanics II
<br>13. Diffusion, friction and entropic forces acting on molecular motors Part I 
<br>14. Diffusion, friction and entropic forces acting on molecular motors Part II
<br>15. Student’s journal club on molecular motors
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<br>六、成績考核(Evaluation)
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<br>期中考及期末報告
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<br>七、可連結之網頁位址
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