1. Course Description:
<br>The course will discuss latest concepts relating to the structure and function of cellular membranes and organelles.  Starting from the physical properties of membranes, the course will examine membrane biogenesis, membrane dynamics, and intracellular trafficking.  Examples will be drawn from specific membrane functions in the various organelles.  Topics will include biogenesis of different cellular organelles and critical issues of trafficking such as protein sorting and targeting.  Latest papers on fundamental aspects of biogenesis and trafficking will be discussed along with the corresponding lectures.
<br>
<br>2. Text Books: N/A
<br>
<br>3. References: 
<br>The Biogenesis of Cellular Organelles.  Landes Biosciences, 2005, ISBN: 0-306-47990-7
<br>Related papers in the latest journals such as Nature, Science, and Cell.
<br>
<br>4. Teaching Method:
<br>English lectures with paper discussions
<br>
<br>5. Syllabus:
<br>Week 1: Introduction
<br>Week 2: Organelle biogenesis
<br>Week 3: Endoplasmic reticulum biogenesis
<br>Week 4: The Golgi apparatus
<br>Week 5: Lysosome biogenesis and dynamics
<br>Week 6: Nucleogenesis 
<br>Week 7: Mitochondrial biogenesis
<br>Week 8: Mid-term-
<br>Week 9: The dynamics of mitochondria morphology
<br>Week 10: The biogenesis and cell biology of peroxisome
<br>Week 11: Protein transport to nucleus 
<br>Week 12: Biogenesis of secretory vesicles
<br>Week 13: ER-Golgi membrane trafficking
<br>Week 14: Protein sorting during endocytosis
<br>Week 15: The biogenesis and human diseases
<br>Week 16: Final Exam
<br>
<br>6. Evaluation:
<br>40% - Mid-term Exam
<br>40% - Final Exam
<br>10% - discussion in the classes
<br>10% - attendance.
<br>
<br>7. Hyperlink:
<br>All the materials will be upload to NTHU moodle e-learning system