轉譯醫學(轉化醫學)
<br>Translational Medicine
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<br>一、課程說明(Course Description)
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<br>Translational medicine can be defined as "bench-to-bedside" research wherein a basic laboratory discovery becomes applicable to the diagnosis, treatment or prevention of a specific disease. We will discuss guidelines for designing and conducting a translational study and analyzing and reporting results and discusses key ethical and regulatory issues. We will also discuss selected successful examples and cover the basic sciences behind them. Physician scientist lecturers will be invited to offer their viewpoints and experiences in lab and clinics.
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<br> 二、指定用書(Textbooks)
<br>"Clinical and Translational Science: principles of human research” 
<br>David Robertson and Gordon H. Williams 
<br>Elsevier/Academic Press, 2009
<br>eBook available at NTHU library  http://www.lib.nthu.edu.tw/
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<br> 三、參考期刊(References)
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<br>Journal of Translational Medicine
<br>http://www.translational-medicine.com/
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<br> 四、教學方式(Teaching Method)
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<br>Lectures; Project; Group Presentation and Discussion
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<br> 五、暫訂教學進度(Syllabus)
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<br>Introduction
<br>Section 1: Planning and Designing Translational Research
<br>1.	Defining the research question
<br>2.	Experimental study designs 
<br>3.	Database development 
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<br>Section 2: Modern Techniques of translational research
<br>1.	Genomics: gene expression profiling, SNP, molecular cloning 
<br>2.	Proteomics
<br>3.	Metabolomics and Cellomics 
<br>4.	Bioimaging : cell and tissue 
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<br>Midterm Evaluation (Group Project Discussion and Presentation) 
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<br>Section 3: Special topics
<br>1.	“Small” clinical research 
<br>2.	Pharmacokinetics and pharmacodynamics
<br>3.	Gene therapy and pharmacogenomic studies 
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<br>Section 4: Example
<br>1.	Cardiovascular diseases 
<br>2.	Cancer 
<br>3.	Neuronal disorder 
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<br>Final Evaluation (Term Paper) 
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<br> 六、成績考核(Evaluation)
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<br>1. Quiz (2) 10% each; and Exam (1) 20%
<br>2. Group project/presentation (1) 30%
<br>3. Term paper (1) 30%
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<br> 七、可連結之網頁位址
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<br>TBA; E-Learning system
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