課程說明

細胞膜的雙極性特性提供了細胞內胞器分隔的場所,此外,細胞膜更是參與了訊號傳遞、蛋白作用、分子運輸等重要的
生理功能。本課程探討細胞膜的生化角色,包含物化特性、脂質合成、訊號調控功能、細胞膜運輸及分子辨識等。

指定用書

Biochemistry of lipids, lipoproteins and membranes, 5th Edition (2008) editors Dennis E. Vance and Jean
E. Vance, Elsevier
Membrane Structural Biology, (2008) by Mary Luckey, Cambridge Univ. Press
Molecular biology of The Cell, 5th Edition (2008) by Bruce Alberts, et al., Garland Science

教學大綱

1. 2/26, Introduction. (SCS & WWu)
2. 3/5, Physical properties and functions of lipids in membranes. (SCS)
3. 3/12, Lipid assembly into cell membranes. (SCS)
4. 3/19, Methods for membrane studying. (SCS)
5. 3/26, Membrane curvature and organelle transport. (WWu)
6. 4/2, Spring break.
7. 4/9, Midterm I.
8. 4/16, Phospholipases and cell signalling. (WWu)
9. 4/23, Lipid raft and sphingolipids. (WWu)
10. 4/30, The eicosanoids pathways and lipid binding domain. (WWu)
11. 5/7 Membrane protein glycosylation and insertion (WWu)
12. 5/14, Midterm II.
13. 5/21, Protein-lipid interaction. (SCS)
14. 5/28, Membrane protein structure and function I. (SCS)
15. 6/4, Membrane protein structure and function II. (SCS)
16. 6/11, Membrane protein insertion and folding. (SCS)
17. 6/18, Final term.