一、課程說明(Course Description)
本課程提供一個簡明且廣泛性縱覽癌症之細胞及分子生物學,涵蓋現今癌症基礎研究與治療。課程內容包括下列主題:癌的起因、遺傳性癌症好發傾向、次遺傳性因子、癌基因、抑癌基因、生長訊號傳遞途徑、基因轉錄體及蛋白質體、細胞週期、基因損傷及修補、基因損傷反應網路系統、細胞衰老、細胞凋亡、微小核醣核酸與癌形成、血管及淋巴管增生、藥物及分子標靶治療。

本課程歡迎具備基礎細胞及分子生物學知識之大學部四年級及研究所學生修讀。

This course provides a concise and comprehensive overview of cancer cellular and molecular biology, covering the current status of both research and treatment. The topics include: the causes of cancer, inherited susceptibility to cancer, epigenetic events in cancer, oncogenes and tumor suppressor genes, growth signaling pathways, transcriptome and proteome, cell cycle control, DNA damage and repair, DNA-damage-response network, senescence, apoptosis, microRNA and cancer, angiogenesis, lymphangiogenesis, metastasis, and drug and molecular targeted therapy.

Undergraduates and postgraduates having cellular and molecular biology background are welcome to take this course.


二、指定用書(Text Books)


三、參考書籍(References)

講義及指定期刊論文。
The Biology of Cancer 2007 Author: Weinberg (藝軒)

四、教學方式(Teaching Method)

講解與評論。引導學生提出問題並參與討論。


五、教學進度(Syllabus)
Syllabus for
Molecular Oncology
(LSBT5747, February 2011 - June 2011, W15:20-6:10)
Lecturer: Jia-Ling Yang

Date Week Topic
February 23 (1) Overview of Molecular Oncology
Cancer Etiology, Epidemiology and Carcinogenesis Mechanisms
March 2 (2) Discovery of Cancer Genes
Cancer Genetic and Specificity
Cancer Detection and Prevention
March 9 (3) Principles of Signal Transduction
Growth Factors and Their Receptors
Protein Tyrosine Kinases and phosphatases
The Ras family
March 16 (4) MAPK Signal Transduction Cascades
PI3K and Akt/PKB Signal Transduction Cascades
Seven-transmembrane-receptor Signaling
Signal Crosstalk and Shutdown
March 23 (5) Integrin and cell motility/adhesion signaling
March 30 (6) Transcription Factors and Cancers
April 6 (7) miRNA and Cancer
April 13 (8) Examination I
April 20 (9) Apoptosis
April 27 (10) NF-kB Signaling
May 4 (11) TGF-b Signaling; Wnt Signaling
May 11 (12) Quality Control by DNA Repair
May 18 (13) Cell Cycle Control I: Control points
May 25 (14) Cell Cycle Control II: Checkpoints
June 1 (15) DNA-damage Checkpoint Signaling I
June 8 (16) DNA-damage Checkpoint Signaling II
June 15 (17) Therapeutic Approach
June 22 (18) Examination II


六、成績考核(Evaluation)
期中考1(25%)期中考2(25%)作業(50%)

七、可連結之網頁位址

iLSM (http://lms.nthu.edu.tw/)