課程名稱:遺傳及基因體研究之分析方法專題(一)
Modeling and Analysis in Genetics and Genomics
99年度上學期
上課時間:T6T7T8
課程大綱:
1. Basic human molecular genetics; genetic information, its transmission
and variations
2. Segregation and related complications; complex diseases; Hardy-
Weinberg laws
3. Genetic markers; types of genetic markers; genotyping methods of SNPs
4. Genotype data quality check and filtering; especially for high-
throughput data
5. Genetic map; linkage disequilibrium
6. Family studies; heritability, segregation analysis
7. Linkage analysis
8. Quantitative traits
9. Family based association tests
10.HapMap project, 1000 Genome Project
10. Genome-wide association studies; case-control studies; fine mapping
11. Microarray expression experiments; introduction to the technology and
analysis methods
12. Expression quantitative treat loci; heritability; intermediate
phenotype
13.Introduction to false discovery rate in genomics studies
14.Introduction to genetic risk prediction