1. Course Description:
<br>The course will discuss latest concepts relating to the structure and function of cellular membranes and organelles.  Starting from the physical properties of membranes, the course will examine membrane biogenesis, membrane dynamics, and intracellular trafficking.  Examples will be drawn from specific membrane functions in various organelles.  Topics will include biogenesis of different cellular organelles and critical issues of trafficking such as protein sorting and targeting.  Latest papers on fundamental aspects of biogenesis and trafficking will be discussed along with the corresponding lectures.
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<br>2. Text Books: N/A
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<br>3. References: 
<br>The Biogenesis of Cellular Organelles.  Landes Biosciences, 2005, ISBN: 0-306-47990-7
<br>Related papers in the latest journals such as Nature, Science, and Cell.
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<br>4. Teaching Method:
<br>English lectures with paper discussions
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<br>5. Syllabus:
<br>1 Introduction
<br>2 Organelle biogenesis
<br>3 Endoplasmic reticulum and EM 
<br>4 The Golgi apparatus maturation
<br>5 Lysosome related organelles
<br>6 Vesicular trafficking
<br>7 Reconstitution of traffic steps
<br>8 Mid-term
<br>9 Mitochondrial biogenesis 
<br>10 Mitochondria morphology and apoptosis 
<br>11 Fission and proliferation of peroxisomes 
<br>12 Actin in membrane trafficking
<br>13 Dynamics of ER and Mitochondria
<br>14 Trafficking and regulation of neuronal voltage-gated calcium channels
<br>15 The biogenesis and human diseases
<br>16 Final
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<br>6. Evaluation:
<br>40% - Mid-term Exam
<br>40% - Final Exam
<br>10% - discussion in the classes
<br>10% - attendance.
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<br>7. Hyperlink:
<br>All the materials and reports will be upload to NTHU iLMS e-learning system
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