Special Topics in Drosophila Eye Development Jui-Chou Hsu

This is a course to discuss the latest advance in the field of cell and developmental biology using mice, Xenopus, Drosophila, and C elegans as model to study cell migration. The following are the examples of papers discussed and will be updated later.

(1) A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration. Developmental Cell 22: 104, 2012.

(2) Abl Regulates Planar Polarized Junctional Dynamics through b-Catenin Tyrosine Phosphorylation. Developmental Cell 22: 309, 2012.

(3) An actin-dependent mechanism for long-range vesicle transport. Nature cell biology 13: 1431, 2011.

(4) Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nature cell biology 13: 1335, 2011.

(5) Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. JCB 196: 115, 2011.

(6) The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway. Developmental Cell 22: 255, 2012.

(7) Endocytosis by Numb breaks Notch symmetry at cytokinesis. Nature cell biology 14: 131, 2012.

(8) Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity. Nature cell biology 13: 1424, 2011.

(9) Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission. Science 334, 1144, 2011.

(10) Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish Embryo. Curr. Biol. 21, 1942, 2011.

(11) Mechanical strain in actin networks regulates FilGAP and integrin binding to filaminA. Nature 478, 260–263, 2011.

(12) Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration. Cell 148, 175, 2012.