課程大綱 (Course Description): 
<br>Prevalence of neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease are closely associated with aging. However, we know very little about the mechanisms underline neural degeneration. The Special Topics on Senescence and Neurodegeneration is designed to bring the latest research related to aging and neuron degeneration to students. The course will focus on discussing the cause-and effect of the cellular senescence models and aging individuals. In addition, the aging effects on the pathological progression of neurodegenerative disorders will be emphasized. The goal of the course is not only to introduce the important health issue of senescence and neurodegeneration to the students, but also to provide logic training via discussion.
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<br>二、指定用書(Text Books): N/A
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<br>三、參考書籍(References):
<br>	Molecular Biology of Aging
<br>Edited By Leonard P. Guarente
<br>CSHL Press, 2008
<br>	Neurodegenerative Diseases (Advances in Experimental Medicine and Biology)
<br>Shamim I. Ahmad
<br>Springer, 2012
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<br>四、教學方式(Teaching Method): 
<br>Lecture combined with latest journal paper discussion.
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<br>五、教學進度(Syllabus):
<br>Week 1: Introduction of Aging and Senescence
<br>Week 2: Cellular senescence model - yeast
<br>Week 3: Senescence model - worm
<br>Week 4: Senescence model - Fly
<br>Week 5: Senescence model - Mouse
<br>Week 6: Aging and mitochondria
<br>Week 7: Oxidative stress, Cancer and Aging
<br>Week 8: Midterm
<br>Week 9: Age-related molecular degenerations
<br>Week 10: Epigenetics in neurodegenerative disorders
<br>Week 11: Disseminated Encephalomyelities
<br>Week 12: Multiple Sclerosis
<br>Week 13: Parkinson’s Disease
<br>Week 14: Alzheimer ’s Disease 
<br>Week 15: Huntington’s Disease
<br>Week 16: Final exam
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