第   週	日  期	Topics
<br>	1	Introduction
<br>	2	Microbial virulence factors
<br>	3	Helicobacter pylori 
<br>	4	Virulence factors of H. pylori
<br>	5	Vacuolating toxin
<br>	6	AB-type toxins and pore-forming toxins
<br>	7	Bacillus anthracis  & Anthrax toxin 
<br>		Bordetella pertussis & Pertussis toxin
<br>		Corynebacterium diphtheriae & diphtheria toxin
<br>	8	Escherichia coli & heat-labile toxin, verotoxin
<br>		Shigella dysenteria & shiga toxin
<br>		Vibrio cholerae & cholera toxin
<br>	9	期中考			
<br>	10	Clostridium tetani & tetanus toxin
<br>		Clostridium botulinum & botulinum toxin
<br>	11	Campylobacter jejuni & cytolethal distending toxin
<br>	12	Pathogen-cell interaction
<br>	13	Phylogenetic perspectives in innate immunity
<br>	14	Secretion machines
<br>	15	Recent topics on bacterial virulence I
<br>	16	Recent topics on bacterial virulence II
<br>	17	Recent topics on bacterial virulence III
<br>	18	期末考
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<br>參考書本
<br>	1. Murray, P. R., Kobayashi, G. S., Pfaller, M. A. & Rosenthal, K. S. (1994). Medical Microbiology. Wolfe.
<br>	2. Alouf, J. E. and Freer, J. H. (1999). Bacterial protein toxins. Academic Press.
<br>	3. Evans, A. S. and Brachman, P. S. (1998). Bacterial Infectioins of Humans.  Epidemiology and Control. Plenum Medical
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