一、課程說明(Course Description)
“Throughout the foreseeable future, research in medicine, molecular biology, and biotechnology will be dominated by scientific advancements resulting form the Human Genome Project. Knowledge of genomes will elucidate disease patterns and promises improved and personalized treatments. Food and drug development will be revolutionized by the focused manipulated of genes and biochemical process.”
– by Prof. Eberhard O. Voit.
本課程兼重學理與實作，藉由習題與範例，使學員能熟悉網路上各種生物資訊之取得及應用，並針對各種常用生物資料庫作概略性的介紹，包括 NCBI, Protein Data Bank (PDB)、 KEGG、ExPasy 等生物資料庫。課程中將連線上網，實際操作、演練各種輔助軟體 (Browser, viewer, molecular displayer...)。
部分內容需具有生科系本科生大二基礎，建議大三以上（含）修讀，學習效果較佳。
二、參考書籍(References)
1. Bioinformatics: a practical guide to the analysis of genes and proteins, Third Edition (http://as.wiley.com/WileyCDA/WileyTitle/productCd-0471478784.html)
The reference is for Gene Module.
三、教學方式(Teaching Method)
在電腦教室上課，課堂講解示範與學生實地操做並行。
四、成績考核(Evaluation)
總成績算法 — Homework 50% / Midterm and final Exam. 50% /
Homework 遲交一天扣該次 homework 成績10%，遲交三天視同未交。
請勿遲到, 遲到兩次以曠課一次論，曠課一次扣總成績十分，曠課三次以不及格論。
五、可連結之網頁位址
NTHU E-Learning System
http://alpha.life.nthu.edu.tw/
六、預定教學進度
Introduction to bioinformatics / Open account, Life Science Alpha Server, NCBI
Protein analysis and prediction / ExPASy
Protein structure database Structural classification / PDB SCOP
Protein structure visualization / Rasmol & Chime
Protein structure modeling & prediction / SWISS-MODEL
Structural comparison / VAST; CE ; Swiss-PdbViewer; SARST
Biology Server and Metabolic Pathways KEGG
Midterm Exam
Network and pathway modeling tool / CellDesigner, CGAP
Biological database mining / NCBI, BLAST, (Primer Design)
Genomic databases / Ensemble, CLUSTALW, Major Model Organism Sites
Predictive methods using primary sequences / GeneID, TRANSFAC, (RE analysis)
Phylogenetic analysis / PHYLIP, Harvester, Expasy
Gene expression profiling / SMD, GeneCard, DAVID (BandScan)
SNP and genotyping / NCBI-SNP, HapMap
Final Exam