轉譯醫學(轉化醫學) Translational Medicine

Textbook: Clinical and Translational Science: principles of human research
David Robertson and Gordon H. Williams; Elsevier/Academic Press, 2009
eBook available at NTHU library http://www.lib.nthu.edu.tw/

一、課程說明(Course Description)
Translational medicine can be defined as "bench-to-bedside" research wherein a basic laboratory discovery becomes applicable to the diagnosis, treatment or prevention of a specific disease. We will discuss guidelines for designing and conducting a translational study and analyzing and reporting results and discusses key ethical and regulatory issues. We will also discuss selected successful examples and cover the basic sciences behind them. Biotech Industry and Physician scientist lecturers will be invited to offer their viewpoints and experiences in lab and clinics.

二、指定用書(Textbooks)
"Clinical and Translational Science: principles of human research”
David Robertson and Gordon H. Williams
Elsevier/Academic Press, 2009
eBook available at NTHU library http://www.lib.nthu.edu.tw/

三、參考期刊(References)
(1) Science Translational Medicine http://stm.sciencemag.org/
(2) Journal of Translational Medicine http://www.translational-medicine.com/

四、教學方式(Teaching Method)
Lectures; Project Presentation and Discussion

五、暫訂教學進度(Syllabus)
See next page

六、成績考核(Evaluation)
1. Attendance and in-class performance (10%_
2. Exam 1 (45%)
3. Exam 2 and/pr Term project ( 45%)

七、可連結之網頁位址
TBA; E-Learning system


暫訂教學進度
Date Instructor Topic Assignment Note
02/25 莊永仁老師 Patient-oriented research;
Training and Career Ch.1
Ch13, Ch14
03/04 莊永仁老師 Experimental approaches:
Molecular Analysis Ch.3, Ch.5
03/11 莊永仁老師 Experimental approaches:
Imaging analysis Ch.6, Ch.7
03/18 莊永仁老師 Nano and Information Technology Ch.8, Ch.9, Ch.10
03/25 莊永仁老師 Infrastructure Ch.11, Ch.12
04/01 莊永仁老師 Drug discovery and development Ch. 22, Ch.25 Redundant?
04/08 楊仲棋醫師 Viewpoint from clinics: Myocardial infarction handout Taoyuan Armed Forces General Hospital
04/15 莊永仁老師 Practice and Regulation Ch.24, Ch.27
04/22 莊永仁老師 Clinical trials and ethical issues Ch.2, Ch.28
04/29 莊永仁老師 Pharmacogenetics Ch.21, Ch.23 Redundant?
05/06 張幸治醫師 Viewpoint from in clinical research: Cancer handout Hsinchu MacKay Memorial Hospital
05/13 莊永仁老師 Pharmocoeconomics Ch.34, CH.36
05/20 莊永仁老師 Future of translational research: Taiwan and beyond Ch.37
Ch16, Ch.18 + Research funding mechanisms
05/27 張書銘醫師 Viewpoint from in clinical research: Epidemiology handout NHRI-Cancer Institute
06/03 劉俞旻醫師
Viewpoint from clinics: Atherosclerosis handout Hsinchu MacKay Memorial Hospital
06/10 莊永仁老師 Project Presentation All students
06/17 No Class No class
06/23 Final week Final Week