課程說明
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<br>細胞膜的雙極性特性提供了細胞內胞器分隔的場所，此外，細胞膜更是參與了訊號傳遞、蛋白作用、分子運輸等重要的
<br>生理功能。本課程探討細胞膜的生化角色，包含物化特性、脂質合成、訊號調控功能、細胞膜運輸及分子辨識等。
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<br>Textbooks: 
<br>Biochemistry of lipids, lipoproteins and membranes, 5th Edition (2008) 
<br>editors Dennis E.  Vance and Jean E. Vance, Elsevier
<br>Membrane Structural Biology, (2008) 
<br>by Mary Luckey, Cambridge Univ. Press
<br>Molecular biology of The Cell, 5th Edition (2008) 
<br>by Bruce Alberts, et al., Garland Science
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<br>教學大綱
<br>2/22	Introduction
<br>2/29	Physical properties and functions of lipids in membranes: Lipid diversity, polymorphisms, lipid motion 
<br>and composition in various organelles (B1 & M2)
<br>3/7 	Lipid assembly into cell membranes: membrane asymmetry, curvature, fatty acid chain elongation and 
<br>lipid transportation (B6, B7 & B16)
<br>3/14	Methods for membrane studying: detergents, hydrophobicity plot, NMR, bioinformatics method and 
<br>etc (M3)
<br>3/21	Membrane protein structure and Mechanism I: classes of membrane proteins, rhodopsin, GPCR, outer 
<br>membrane proteins, apolipoprotein (M6, M10 & B17)
<br>3/28	Membrane protein structure and Mechanism II: channel, transporter, ATPase (M9 & M11)
<br>4/4	Holiday 
<br>4/11	Protein-lipid interaction: interaction force between protein and lipid, protein behaviour in membrane 
<br>(pka, lipid phase, hydrophobic mismatch, hydrogen bond and etc) (M4 & M5)
<br>4/18	Mid term 
<br>4/25	Membrane protein insertion and folding (M7)
<br>5/2	Structural Studies on Membrane Proteins I: Membrane protein preparation, 2D & 3D Membrane 
<br>Protein Crystallography, Cryo-EM, X-ray and Free Electron Laser
<br>5/9	Lipoprotein structure and function
<br>5/16	Phospholipases and cell signalling (B11)
<br>5/23	Biophysical Society meeting
<br>5/30 	Organelle transport (C13; Nature, 2010, 463, 439; 464-473)
<br>6/6		 
<br>6/13	Final Term
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