1. Course Description:
<br>Autophagy is an emerging research topic. Special topics on autophagy and disease will discuss the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes. In addition, this course will cover the current understanding of the roles of autophagy in health and disease. The students are expect to learn major concepts in autophagy research and current trend of drug development strategies targeting autophagy.
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<br>2. Text Books: N/A
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<br>3. References: 
<br>i) Autophagy in Health and Disease
<br>  Roberta A. Gottlieb (Editor)
<br>  Publisher: Academic Press; 1 edition (October 30, 2012)
<br>ii) Autophagy: Principles, Regulation and Roles in Disease
<br>  Nikolai Gorbunov (Editor)
<br>  Publisher: Nova Science Publishers (November 30, 2012)
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<br>4. Teaching Method:
<br>Lectures with discussions of latest journal paper.
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<br>5. Syllabus:
<br>Week 1: Introduction of autophagy
<br>Week 2: Regulatory pathway of autophagy
<br>Week 3: Cell death and autophagy
<br>Week 4: The ubiquitin-proteasome system
<br>Week 5: Chaperone-mediated autophagy
<br>Week 6: Endocytic pathway and autophagy
<br>Week 7: Mitophagy
<br>Week 8: Midterm
<br>Week 9: Autophagic regulation of neuritic/synaptic processes
<br>Week 10: Autophagy and neurodegenerative disorders
<br>Week 11: Autophagy and ischemia/hypoxia
<br>Week 12: Autophagy and lysosomal storage diseases
<br>Week 13: Autophagy and cancer
<br>Week 14: Autophagy and infectious diseases
<br>Week 15: Drug development strategies targeting autophagy.
<br>Week 16: Final exam
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<br>6. Evaluation:
<br>Mid-term: 35%
<br>Final exam: 40%
<br>Presentation: 25%
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<br>7. Webpage:
<br>All materials will be upload to the NTHU iLMS system
<br>http://lms.nthu.edu.tw/
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