Current Topics in Signal Transduction   Jui-Chou Hsu
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<br>This is a course to discuss the latest advance in the field of cell and developmental biology using mice, Xenopus, Drosophila, and C elegans as model to study cell migration. The following are the examples of papers discussed and will be updated later. 
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<br>(1)	Mitotic cell rounding accelerates epithelial invagination. Nature 494, 125–129, 2013
<br>(2)	Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast.   JCB 200, 271-286, 2013.
<br>(3)	RabGEFs are a major determinant for specific Rab membrane targeting. JCB 200, 287-300, 2013.
<br>(4)	Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape. JCB 200, 95-108, 2013.
<br>(5)	Generation of Leaf Shape Through Early Patterns of Growth and Tissue Polarity.  Science 335, 1092, 2012.
<br>(6)	Golgi Outposts Shape Dendrite Morphology by Functioning as Sites of Acentrosomal Microtubule Nucleation in Neurons. Neuron 76, 921–930, 2012.
<br>(7)	Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation. Dev. Cell 23, 939–953, 2012
<br>(8)	Intracellular lumen extension requires ERM-1-dependent apical membrane
<br>expansion and AQP-8-mediated flux. Nature cell biology 15, 143, 2013.
<br>(9)	Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nature cell biology 15, 189, 2013.
<br>(10)	Mechanical force regulates integrin turnover in Drosophila in vivo. Nature cell    
<br>biology 14, 935, 2012.
<br>(11)	Regulation of Microtubule Stability and Organization by Mammalian Par3
<br>in Specifying Neuronal Polarity. Developmental Cell 24, 26–40, 2013
<br>(12)	The First Five Seconds in the Life of a Clathrin-Coated Pit. Cell 150, 495–507,       
<br>2012.
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