一、課程說明(Course Description)
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<br>Transcription Factor Forkhead Box (Fox) protein family members regulate 
<br>transcriptional network of genes control multiple cellular physiology.  Among 
<br>them, FoxM1 and FoxO are two subclass proteins have been identified as important 
<br>transcription factors in development, cancer and other diseases.  This course 
<br>aims to help students understand the molecular mechanism and biological roles of 
<br>FoxM1 and FoxO by covering the following issues: 1)Biological functions of 
<br>Forkhead box family transcription factors; 2) Fox proteins transcriptional 
<br>regulate cell cycle progression; 3) Fox target genes and regulatory signal 
<br>pathways; 4) Fox proteins in mouse embryonic development; 5) Fox proteins in 
<br>cancer biology; 6) Cross talks between Fox proteins and related diseases.
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<br>二、指定用書(Text Book)
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<br>三、參考書籍(References)
<br>Selected papers
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<br>四、教學方式
<br>Lecture/ Seminar /Discussion
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<br>五、教學進度
<br>2/17	Introduction to Fox transcription factors
<br>2/24	Discovery of Foxm1 and liver transcription factors
<br>3/3	Molecular analysis of Foxm1 protein
<br>3/10	Fox family in cell cycle regulation  
<br>3/17	Fox family, SCF and Protein degradation
<br>3/24	Fox family in lung and liver cancers
<br>3/31	Fox family in ovary and colorectal cancers 
<br>4/7	Fox family in embryo development
<br>4/14	Fox family in lung development and maturation
<br>4/21	Fox O and FoxM1 in oxidative stress response
<br>4/28	Fox O and FoxM1 in diabetes
<br>5/5	Aging Foxes
<br>5/12	Fox family in injury-repair process
<br>5/19	Fox and stem cells
<br>5/26      The crosstalk between FoxO and FoxM1
<br>6/2     (Holiday: Dragon Boat Festival)
<br>6/9	Overview of the other Foxes
<br>6/16	Final exam
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<br>六、成績考核
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<br>Attendance 10%
<br>Discussion/Seminar 60%
<br>Mid-term and Final report 30%
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<br>七、講義位址
<br>    http://lms.nthu.edu.tw/
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