課程大綱 (Course Desc<x>ription): 
<br>Prevalence of neurodegenerative disorders such as Parkinson’s disease and 
<br>Alzheimer’s disease are closely associated with aging. However, we know very 
<br>little about the mechanisms underline neural degeneration. The Special Topics 
<br>on Mitochondria, Senescence and Neurodegeneration is designed to bring the 
<br>latest research related to aging and neuron degeneration to students. The 
<br>course will focus on discussing the cause-and effect of the cellular 
<br>senescence models and aging individuals. In addition, the aging effects on the 
<br>pathological progression of neurodegenerative disorders will be emphasized. 
<br>The goal of the course is not only to introduce the important health issue of 
<br>senescence and neurodegeneration to the students, but also to provide logic 
<br>training via discussion.
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<br>二、指定用書(Text Books): N/A
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<br>三、參考書籍(References):
<br>Molecular Biology of Aging
<br>Edited By Leonard P. Guarente, CSHL Press, 2008
<br>Neurodegenerative Diseases (Advances in Experimental Medicine and Biology)
<br>Shamim I. Ahmad, Springer, 2012
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<br>四、教學方式(Teaching Method): 
<br>Lecture combined with latest journal paper discussion.
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<br>五、教學進度(Syllabus):
<br>Week 1: Introduction of Aging and Senescence
<br>Week 2: Cellular senescence model - yeast
<br>Week 3: Senescence model - worm
<br>Week 4: Senescence model - Fly
<br>Week 5: Senescence model - Mouse
<br>Week 6: Aging and mitochondria
<br>Week 7: Oxidative stress, Cancer and Aging
<br>Week 8: Midterm
<br>Week 9: Age-related molecular degenerations
<br>Week 10: Epigenetics in neurodegenerative disorders
<br>Week 11: Disseminated Encephalomyelities
<br>Week 12: Multiple Sclerosis
<br>Week 13: Parkinson’s Disease
<br>Week 14: Alzheimer ’s Disease 
<br>Week 15: Huntington’s Disease
<br>Week 16: Final exam
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