一、課程說明(Course Description)
“Throughout the foreseeable future, research in medicine, molecular biology, and
biotechnology
will be dominated by scientific advancements resulting from the Human Genome
Project.
Knowledge of genomes will elucidate disease patterns and promises improved and
personalized
treatments. Food and drug development will be revolutionized by the focused
manipulated of
genes and biochemical process.”
– by Prof. Eberhard O. Voit.
二、參考書籍(References)
1. Bioinformatics: a practical guide to the analysis of genes and proteins,
Third Edition
(http://as.wiley.com/WileyCDA/Wileytitle/productCd-0471478784.html)
The reference is for Gene Module.
2. Biological sequence analysis - Probabilistic models of proteins and nucleic acids, by
Durbin etc
3. Molecular Modelling: Principles and Applications (2nd Edition), by Andrew Leach
三、教學方式(Teaching Method)
在電腦教室(R202, 生科二館)上課,課堂講解示範與學生實地操做並行。
四、成績考核(Evaluation)
Prof Ng's 5 homework take 30%
Prof Lyu's 3 homework take 25%
Prof Yang's 1 homework (15%) + two quizzes (10%) take 25%
The final exam takes 20%
Homework 遲交一天扣該次 homework 成績10%,遲交三天視同未交。
五、可連結之網頁位址
NTHU iLMS System
https://lms.nthu.edu.tw/
六、預定教學進度
Date_____ Topics
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9/13 Intro (Yang)
9/20 DNA and Amino Acid Sequence Evolution (Ng)
9/27 Molecular Phylogenetics (Ng)
10/4 Mid-Autumn Festival Holiday
10/11 NGS & Genomics (Ng)
10/18 Functional Genomics & Transcriptomics (Ng)
10/25 Genome Databases and Resources (Ng)
11/1 Dynamic Programming I (Yang)
11/8 Dynamic Programming II (Yang)
11/15 School Game Day
11/22 Protein Structure Databases (Lyu)
11/29 Protein Structure Visualization (Lyu)
12/6 Protein Structure Analysis (Lyu)
12/13 Structural Comparison (Lyu)
12/20 Protein Structure Modeling & Prediction (Lyu)
12/27 Docking + Protein Dynamics (Yang)
1/3 Machine Learning (Yang)
1/10 Final