一、課程說明
The primary focus of this course is on the tumors reprogram pathways of nutrient
acquisition and metabolism acquired by malignant cells to meet their
bioenergetics, biosynthetic, and redox demands. We will discuss these
reprogrammed activities in the specific pathways mediated by key enzymes to
support the survival and proliferation of tumor cells. The underlying mechanisms
linking cancer metabolism to tumorigenesis and metastasis is also discussed.
二、指定用書
metabolism in cancer, Recent Results in Cancer Research, Volume 207, 2016.
Edited by Thorsten Cramer and Clemens A. Schmitt.
三、參考書籍
Tumor Cell metabolism: Pathways, Regulation and Biology. Edited by Sybille
Mazurek and Maria Shoshan. Springer
四、教學方式
Lectures and Interactive Discussions.
五、教學進度
Overview of metabolism
Bioenergetics of ATP and NADH
metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
MYC, metabolic Synthetic Lethality, and Cancer
Glucose and Lipid metabolism in Growth and Survival of Cancer Cells
Redox Balance
Biosynthesis of Macromolecules
Targeting metabolism for Cancer Therapy
New Technologies in Cancer metabolism
六、成績考核
Evaluation attendance, midterm exam and final exam
七、講義位址
http:// http://lms.nthu.edu.tw/home.php