一、課程說明(Course Desc<x>ription)
<br>Focus on the emerging areas of lung epithelial biology and the critical issues 
<br>on 
<br>normal lung development and diseases. Current subjects of lung research field 
<br>such as interaction of epithelial and stroma, immune interaction, as well as 
<br>regulatory signaling pathways will be introduced and discussed. The course aims 
<br>to help students understand the fundamental and molecular mechanism of health 
<br>and 
<br>diseased lungs by covering following issues: (1) Lung epithelia development (2) 
<br>lung biology and maintenance of lung function (3) epithelia-mesenchyme 
<br>interaction (4) Acute and chronic pulmonary diseases (5) lung cancer initiation 
<br>and me<x>tastasis (6) normal lung stem cell and lung cancer stem cells. 
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<br>二、指定用書(Text Books)
<br>Selected papers
<br>
<br>三、參考書籍(References)
<br>Selected papers
<br>
<br>四、教學方式(Teaching Method)
<br>Lecture/ Seminar /Discussion
<br>
<br>五、教學進度(Syllabus)
<br>
<br>02/18 Overview of lung biology 
<br>02/25 Genetic control of lung development
<br>03/04 Signal transduction in branch morphogenesis and airway development
<br>03/11 Surfactant proteins and lipids in lung function
<br>03/18 Surfactant proteins and lipids in lung function
<br>03/25 Surfactants and Respiratory distress syndrome and lung homeostasis
<br>04/01 Acute lung injury, epithelial repair and lung regeneration
<br>04/08 Holiday
<br>04/15 Epithelial-mesenchymal interrelationships
<br>04/22 Lung homeostasis
<br>04/29 Stem cells and epithelial cell plasticity
<br>05/06 Overview of lung cancers/Lung cancer mouse models 
<br>05/13 Transc<x>riptional regulation in lung cancer initiation/me<x>tastasis
<br>05/20 EGFR mutations and lung cancer drug resistance
<br>05/27 Lung cancer drug resistance and lung cancer stem cell
<br>06/03 Lung Inflammation and asthma 
<br>06/10 Macrophages, inflammation, and lung cancer
<br>06/18 Final term
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<br>六、成績考核(Evaluation)
<br>Attendance 20%
<br>Discussion/Seminar 80%
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<br>