一、課程說明
<br>The nucleus is the hallmark of eukaryotic cells that housing DNA in a membrane-enclosed compartment. The 
<br>emergence of nucleus during evolution offered a more sophisticated regulation for decoding genetic 
<br>information, which ultimately drove the evolvement of multicellular organisms. Thus, the maintenance of 
<br>nuclear structure and organization is key to the function of all eukaryotic cells. In this class, we will discuss 
<br>topics relate to (1) the nuclear envelope, (2) the nuclear lamins, (3) the lamin-binding proteins, (4) the 
<br>nuclear 
<br>pore complex, (5) the nucleoplasm and cytoplasm transport, (6) the functional organization of the nucleolus, 
<br>(7) the nuclear proteolysis, and (8) the nuclear structure maintenance.   
<br>二、指定用書
<br>The nucleus, by&#160;Tom Misteli and David L. Spector
<br>‧	ISBN-10:&#160;0879698942
<br>三、參考書籍
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<br>四、教學方式
<br>Student presentation and paper review (in English)
<br>五、教學進度
<br>(1) nuclear envelope (three weeks)
<br>(2) nuclear lamins (two weeks)
<br>(3) lamin-binding proteins (one week) 
<br>(4) the nuclear pore complex (one week)
<br>(5) nucleoplasm and cytoplasm transport (two weeks) 
<br>(6) the functional organization of the nucleolus (two weeks) (7) the nuclear proteolysis (two weeks) 
<br>(8) the nuclear structure maintenance (two weeks)
<br>40 min presentation and 1 hour discussion/paper review for each class
<br>六、成績考核
<br>Presentation (50%)
<br>Summary report (30%)
<br>Class participation (20%)
<br>