一、課程說明(Course Description)
In 1863, Prof. Virchow postulated that chronic irritation and previous
injuries are a precondition for tumorigenesis. In 1986, Dr. Dvorak recognized
that the composition of the tumor stroma strongly resembles the granulation
tissue of healing skin wounds and postulated that "tumors are wounds that do
not heal“ in NEJM. In 2011, Dr. Weinberg concluded that in
addition to cancer cells, tumors exhibit another dimension of complexity: they
contain a repertoire of recruited, ostensibly normal cells that contribute to
the acquisition of hallmark traits by creating the "tumor microenvironment“.
Rather than a single cell disease, the system involved in aberrant wounding
and chronic inflammation is also responsible for patients poor outcome.
Although the advances in science are changing what we know about cancer
complexity, there is still no efficient method to differentiate the cancer
attributes between patients. We will discuss the issue in the class.
The prerequisites for this course are Tumor biology I or Tumor Biology II. The
course is a continuation of Tumor Biology (I or II).
二、指定用書(Text Books)
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM,
Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ,
Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF (2018) Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nat Med 24: 541-550
Cassetta L, Pollard JW (2018) Targeting macrophages: therapeutic approaches in
cancer. Nat Rev Drug Discov
Chen X, Song E (2018) Turning foes to friends: targeting cancer-associated
fibroblasts. Nat Rev Drug Discov
David CJ, Massague J (2018) Contextual determinants of TGFbeta action in
development, immunity and cancer. Nat Rev Mol Cell Biol 19: 419-435
Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B,
Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT,
Hiratsuka S, Ghajar CM, Lyden D (2017) Pre-metastatic niches: organ-specific
homes for metastases. Nat Rev Cancer 17: 302-317
Ribatti D, Tamma R (2018) A revisited concept. Tumors: Wounds that do not
heal. Crit Rev Oncol Hematol 128: 65-69
Taniguchi K, Karin M (2018) NF-kappaB, inflammation, immunity and cancer:
coming of age. Nat Rev Immunol 18: 309-324
三、參考書籍(References)
四、教學方式(Teaching Method)
Pre-read the teaching material, and discuss in the class.
五、教學進度(Syllabus)
六、成績考核(Evaluation)
attendance, participation in the class, final report
七、可連結之網頁位址