課程說明 (Course Desc<x>ription)
<br>本課程基本上探討核磁共振技術近年來最新的進展及運用。我們將選定近五年內特定且具代表性及重要性的新
<br>技術作探討，選定的課題在核磁共振光譜上，有著較高的應用性及重要性。本課程不是核磁共振光譜入門課程，
<br>適
<br>合對核磁共振技術有基礎且有興趣的學生修習，例如修過核磁共振原理、生物核磁共振導論或其他相關課程。
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<br>教學方式 (Teaching Method)
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<br>上課講解加上口頭報告
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<br>教學進度 (Syllabus)
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<br>A paticular topic will be discussed every week in the course. We focus on the new 
<br>development in 
<br>certain 
<br>NMR technique or application with high impact. The selected topics are listed as 
<br>below. Any other 
<br>interesting topics will be incorporated if necessary.
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<br>1.	Spectroscopy for macromolecular proteins (M.W. > 100 kDa) in solution.
<br>2.	Segmental isotopic labelling.
<br>3.	Cell free method in NMR spectroscopy.
<br>4.	Determine global fold by spin labelling.
<br>5.	Spectroscopy in organic solvent and inverted micelle.
<br>6.	Angular restraints for structural refinement.
<br>7.	Hydrogen bond scalar coupling.
<br>8.	Identification and characterization of the binding of ligands to proteins.
<br>9.	In-Cell NMR.
<br>10.	R2 relaxation dispersion experiment.
<br>11.	Protein NMR study in aggregation state.
<br>12.	Protein folding.
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