1. Course Desc<x>ription:
<br>The course of Epigenetics and epigenome is focus on the study of stable 
<br>genetic modifications that result in changes in gene ex<x>pression and 
<br>function 
<br>without a corresponding alteration in DNA sequence. The epigenome is refereed 
<br>to a catalog of the epigenetic modifications that occur in the genome. Many 
<br>diseases have associated with epigenetics changes. New methods to detect the 
<br>modifications and better understandings of factors that drive these changes 
<br>have made progress in this field. Thus, this course is designed to introduce 
<br>the concepts and the new developments of epigenetics to students. Latest 
<br>papers related to epigenetics will be discussed along with the 
<br>corresponding lectures.
<br>
<br>2. Text Books: N/A
<br>
<br>3. References: 
<br>Epigenetics, Cold Spring Harbor Laboratory Press, 2007, ISBN  978-087969875-1
<br>Related papers in the latest journals such as Nature, Science, and Cell.
<br>
<br>4. Teaching Method:
<br>English lectures with paper discussions
<br>
<br>5. Syllabus:
<br>Week 1: Introduction
<br>Week 2: The rise of Epigenetics
<br>Week 3: Euchromatin and Heterochromatin
<br>Week 4: Silent Chromatin
<br>Week 5: Position Effects
<br>Week 6: Nucleosome and chromatin assembly 
<br>Week 7: Chromatin dynamics
<br>Week 8: Mid-term
<br>Week 9: Histone modification code
<br>Week 10: Transc<x>ription activation
<br>Week 11: Gene suppression
<br>Week 12: Cohesion and gene repression
<br>Week 13: RNA and gene regulation
<br>Week 14: Epigenome
<br>Week 15: Epigenetics and diseases
<br>Week 16: Final Exam
<br>
<br>6. Evaluation:
<br>40% - Mid-term Exam
<br>40% - Final Exam
<br>10% - discussion in the classes
<br>10% - attendance.
<br>
<br>7. Hyperli<x>nk:
<br>http://lms.nthu.edu.tw/