一、課程說明	
<br>The primary focus of this course is on the tumors reprogram pathways of nutrient 
<br>acquisition and me<x>tabolism acquired by malignant cells to meet their 
<br>bioenergetics, biosynthetic, and redox demands. We will discuss these 
<br>reprogrammed activities in the specific pathways mediated by key enzymes to 
<br>support the survival and proliferation of tumor cells. The underlying mechanisms 
<br>li<x>nking cancer me<x>tabolism to tumorigenesis and me<x>tastasis is also 
<br>discussed.
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<br>二、指定用書	
<br>me<x>tabolism in cancer, Recent Results in Cancer Research, Volume 207, 2016. 
<br>Edited by Thorsten Cramer and Clemens A. Schmitt.
<br>
<br>三、參考書籍	
<br>Tumor Cell me<x>tabolism: Pathways, Regulation and Biology. Edited by Sybille 
<br>Mazurek and Maria Shoshan. Springer
<br>
<br>四、教學方式	
<br>Lectures and Interactive Discussions.
<br>
<br>五、教學進度	
<br>Overview of me<x>tabolism
<br>Bioenergetics of ATP and NADH
<br>me<x>tabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
<br>MYC, me<x>tabolic Synthetic Lethality, and Cancer
<br>Glucose and Lipid me<x>tabolism in Growth and Survival of Cancer Cells
<br>Redox Balance
<br>Biosynthesis of Macromolecules
<br>Targeting me<x>tabolism for Cancer Therapy
<br>New Technologies in Cancer me<x>tabolism 
<br>
<br>六、成績考核	
<br>Evaluation attendance, midterm exam and final exam
<br>
<br>七、講義位址
<br> http://lms.nthu.edu.tw/home.php
<br>