一、	課程說明
<br>Course Desc<x>ription	The proposed lecture focuses on the regulation of cell cycle progression, especially mitotic progression control and its possible implication in the development of chromosome instability and cancer. 
<br>二、	指定用書
<br>Text Books	
<br>三、	參考書籍
<br>References	The Cell Cycle- Principles of Control. David O Morgan, New Science Press Ltd
<br>四、	教學方式
<br>Teaching Method	Give lectures and discuss with students
<br>五、	教學進度
<br>Syllabus	See below information
<br>六、	成績考核
<br>Evaluation	Attendance, midterm exam and final exam
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<br>大綱
<br>I.	Cell cycle overview
<br>Just to give a comprehensive understanding the events of the eukaryotic cell cycle and their basic control system
<br>II.	Model organisms for the study in cell cycle control
<br>To introduce several model organisms which are used to study the cell cycle control. Explain and describe the unique features for each organism. Yeast (both budding and fission), Xenopus laevis, Drosophila melanogaster and mammalian systems will be discussed.
<br>III.	Basic cell cycle control system
<br>Introduction of major components of basic cell cycle control machinery including cyclin dependent kinases, cyclin, anaphase promoting complex (APC) and their regulation. 
<br>IV.	DNA replication/Chromosome duplication
<br>A brief introduction of chromosome duplication in G1/S phase and its regulation. 
<br>V.	Entry into mitosis
<br>Discuss about the events that control the mitotic entry. Explain what do cell do to get an access into mitosis. 
<br>VI.	The mitotic spindle assembly
<br>Introduce the process of mitotic spindle formation, the role of chromosome structure, spindle pole body separation, cell geometry for bi-orientation, and the kinetochore attachments. 
<br>VII.	The spindle assembly checkpoint – the activation and maintenance
<br>Describe how does SAC monitor both the kinetochore-microtubule attachment and tension in-between sister chromatids and how the “wait-anaphase” signal is maintained or activated before anaphase onset.
<br>VIII. The spindle assembly checkpoint – the satisfaction and silencing
<br>Discuss the subsequent event when SAC is satisfied. The control for anaphase onset by the activation of separase, cdc14, APC/C and inactivation of cyclin B/Cdk1.
<br>IX. Cytokinesis
<br>Describe how does a cell execute division of cytoplamic components and perform abscission after chromosome separation.
<br>X. On the road to cancer: mitotic adaptation, slippage, catastrophe and aneuploidy
<br>Discuss what happens when cells can not satisfy the SAC, the outcome of mitotic adaptation, slippage, catastrophe and aneuploidy caused by the failure in mitosis.
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