Course：Glycobiology - Principle, Disease and Application
<br>    醣類生物學 — 原理‧疾病及應用 (11020LSBS535100)
<br>Lecturer：Wen-guey WU 吳文桂 (LS Build II: room 206)  
<br>Time:     Thursday afternoon R6R7 (14:20-16:10)   
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<br>Cell consists of biomolecules of DNA/RNA，protein, lipid and carbohydrates for its function, but our understandings of cellular structure and function have been mainly focused on DNA/RNA and proteins.  Recent technological advances in knock-out mice, siRNA and MASS spectroscopy, however, have gradually changed the situation to allow the structural and functional characterization of lipidomics and glycomics. In this course, we will provide the historical background and evaluate the structural basis and functional role of several biologically important glycoconjugates such as N-Glycans, O-Glycans, Glycosphingolipids and Proteoglycans. Issues relating to the role of glycans in cell signal/development and human disease will then be discussed by using literatures available within the last couple years.
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<br>1st  Week	Feb17	Historical Background & Structural Diversity
<br>2nd  Week Feb24  Carbohydrate Structure 
<br>3rd   Week 	Mar03	Glycosylation effect on Structure and Function 
<br>4th  Week	Mar10	Midterm I (15%)
<br>5th  Week	Mar17	Glycoconjugates I:  Structure and Function of N-Glycan 
<br>6th  Week	Mar24	Glycoconjugates II: Structure and Function of O-Glycan
<br>7th  Week	Mar31	Glycoconjugates III:Structure and Function of Glycolipids
<br>8th  Week	Apr07	Glycoconjugates IV: Glycosaminoglycans and GPI anchor 
<br>9th  Week	Apr14	Glycosylation on protein secretion and quality control 
<br>10th Week	Apr21	Midterm II (25%)
<br>11th Week	Apr28	Glycan recognition I: Cell adhesion
<br>12th Week May05  Glycan recognition II: Cell signaling
<br>13th Week	May12	Glycobiology of Plant, Bacteria and Virus
<br>14th Week	May19	Glycobiology and Development
<br>15th Week	May26	Glycobiology and Diseases (30%)
<br>16th Week Jun02	Oral presentation (30%)
<br>17th Week Jun09	Final Examination	
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<br>1. Introduction to Glycobiology (3rd Edition) (by Maureen E. Taylor Kurt  Drickamer,Oxford) (2011) 
<br>2. Essentials of Glycobiology (3rd Edition) (by Ajit Varki, Cold Spring Harbor, NY,USA: Cold Spring Harbor Laboratory Press) (2017) (NCBI download http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=glyco2)
<br>3. Assigned reading and review articles 
<br>4. Grade: (I)Midterm (40%)、(II)Oral(30%)、(III)Final(30%)
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