一、課程說明
<br>Transc<x>ription Factor Forkhead Box (Fox) protein family members regulate 
<br>transc<x>riptional network of genes control multiple cell physiology.  Among them, 
<br>FoxM1 protein has been identified as an important transc<x>ription factor in 
<br>development, cancer, aging and other diseases. This course extends the setting 
<br>from Forkhead Box protein special topics (I) and aims to help students understand 
<br>the molecular mechanism and biological roles of FoxM1, especially lung and 
<br>pancreas. The content involves major issues are as follows: 1) Regulation of 
<br>Forkhead box M1 transc<x>ription factors; 2) Gene transc<x>riptional regulation by 
<br>FoxM1 
<br>protein; 3) FoxM1 target genes and regulatory signal pathways; 4) FoxM1 protein in 
<br>mouse organogenesis; 5) FoxM1 protein in cancer initiation and progression; 6) Fox 
<br>proteins oxidative stress and mitochondria function and dynamics. 7) Macrophage 
<br>polarization.
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<br>二、指定用書	Selected papers
<br>三、參考書籍	Selected papers
<br>四、教學方式	Lecture/ Seminar /Discussion
<br>五、教學進度	
<br>Week1	Introduction to FoxM1 transc<x>ription factor
<br>Week2	Discovery of Foxm1 and its functions
<br>Week3	Molecular analysis of FoxM1 protein domains
<br>Week4	FoxM1 family in cell cycle regulation  
<br>Week5	FoxM1 in lung cancer initiation
<br>Week6	FoxM1 in lung cancer maintenance and progression
<br>Week7	FoxM1 in lung cancer me<x>tastasis and EMT
<br>Week8	FoxM1 in cancer drug resistance
<br>Week9	FoxM1 in embryonic development
<br>Week10	FoxM1 in lung development and maturation
<br>Week11	FoxM1 in lung injury and repair
<br>Week12	FoxM1 in oxidative stress and mitochondria
<br>Week13	FoxM1 in pancreatic cancer development
<br>Week14	FoxM1 in stem cells and cancer origin
<br>Week15	The crosstalk between FoxM1 and Wnt signaling
<br>Week16	The crosstalk between FoxM1 and SHH signaling
<br>Week17	FoxM1 in macrophage polarization
<br>Week18	Final term
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<br>六、成績考核	Attendance 10%
<br>Discussion/Seminar 30%
<br>Mid-term and Final report 60%
<br>七、講義位址
<br>    NTHU eeclass 數位學習平台	
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