Text Books: N/A

References: Methods in Enzymology Volume 646 (January 2021)

Teaching Method: English lecture combined with latest journal paper discussion.

Syllabus:
Week 1: Introduction
Week 2: Basic Concepts of liquid–liquid phase separation
Week 3: Method to study LLPS
Week 4: Sequence-specific coarse-grained model
Week 5: Cell-free reconstitution of multi-condensate assemblies
Week 6: Characterizing the material properties of biomolecular condensates
Week 7: Measuring the activity and structure condensates inside liquid-liquid
phase separation
Week 8: Panel discussion
Week 9: Mid-term
Week 10: LLPS and diseases
Week 11: Alzheimer/Parkinson diseases and LLPS
Week 12: Frontotemporal dementia and LLPS
Week 13: Amyotrophic lateral sclerosis and LLPS
Week 14: Cancer and LLPS
Week 15: SARS-CoV-2 and LLPS
Week 16: LLPS, organelles and pathogenesis
Week 17: Panel discussion
Week 18: Final Exam

Evaluation:
40 % - Mid-term Exam
40 % - Final Exam
15 % - Discussion in the classes
5 % - Attendance

Website:
E-learning platform: eeclass of National Tsing Hua University