一、課程說明
<br>本門課程旨在介紹(1)金屬生物醫藥的設計、合成以及功能、(2)金屬酵素的合成以及作用機制
<br>以
<br>及(3)金屬金醫材料的設計與開發。於學期末則安排由學生挑選相關主題，進行口頭報告。
<br>
<br>This class aims to introduce (1) functional design and synthesis of me<x>tal-
<br>ba<x>sed biomedicine, (2) synthesis, function, and reaction mechanism of 
<br>me<x>talloenzymes, and the functional design and synthesis of me<x>tal-
<br>ba<x>sed 
<br>biomaterials. In the end of the semester, students have to choose a topic and 
<br>give an oral presentation relevant to the application of me<x>tal chemistry in 
<br>biomedical engineering. 
<br>
<br>二、指定用書
<br>上課講義
<br>
<br>三、參考書籍
<br>1. Principles of Bioinorganic Chemistry.
<br>Stephen J. Lippard, Jeremy M. Berg.
<br>ISBN: 0935702725
<br>2. Biological Inorganic Chemistry
<br>Ivano Bertini, Harry B. Gray, Edward I. Stiefel, Joan S. Valentine
<br>ISBN:1891389432
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<br>四、教學方式
<br>(1) 講授 Lecture
<br>(2) 口頭報告 Oral presentation
<br>(3) 課堂討論
<br>
<br>五、教學進度
<br>Week 1 
<br>課程簡介 Introduction
<br>Week 2 
<br>基礎生物分子回顧與介紹 Review of biomolecules
<br>Week 3 
<br>基礎化學與無機化學回顧與介紹 Review basic and inorganic chemistry
<br>Week 4 
<br>鈉、鉀、鈣、鎂離子在生物體中的功能 
<br>Function of Na, K, Ca, and Mg ions in biological system  
<br>Week 5 
<br>國定假日 National Holiday
<br>Week 6 
<br>含鐵金屬酵素的發現、結構、功能 
<br>Discovery, structure, and function of Fe-containing me<x>talloenzyme 
<br>Week 7 
<br>含銅、鋅金屬酵素的發現、結構、功能
<br>Discovery, structure, and function of Cu/Zn-containing me<x>talloenzyme
<br>Week 8 
<br>含其他金屬酵素的發現、結構、功能 
<br>Discovery, structure, and function of other me<x>talloenzyme
<br>Week 9 
<br>具生醫應用的金屬錯合物：cis-platin抗癌藥物
<br>me<x>tal complexes for biomedical application: anti-cancer drug cis-platin
<br>Week 10 
<br>具生醫應用的金屬錯合物：Tc/Gd/Mn/Fe3O4生物影像顯影劑
<br>me<x>tal complexes for biomedical application: contrast reagent for bioimaging
<br>Week 11 
<br>具生醫應用的金屬錯合物：一氧化氮/一氧化碳傳遞
<br>me<x>tal complexes for biomedical application: Delivery of nitric oxide/carbon 
<br>monoxide
<br>Week 12 
<br>具生醫應用的金屬錯合物：藥物傳遞金屬奈米材料
<br>me<x>tal complexes for biomedical application: me<x>tal nanomaterial for drug 
<br>delivery
<br>Week 13 
<br>具生醫應用的金屬錯合物：檢測用金屬奈米粒子
<br>me<x>tal complexes for biomedical application: me<x>tal nanoparticle for 
<br>diagnosis
<br>Week 14 
<br>具生醫應用的金屬錯合物：基因傳遞金屬奈米粒子
<br>me<x>tal complexes for biomedical application: me<x>tal nanoparticle for gene 
<br>delivery
<br>Week 15 
<br>期末考 Final exam
<br>Week 16 
<br>期末報告 Oral Presentation
<br>Week 17 
<br>國定假日 National Holiday
<br>Week 18 
<br>期末報告 Oral Presentation
<br>
<br>六、成績考核
<br>期末考 Final exam (50%)
<br>期末報告 oral presentation (50%)
<br>
<br>
<br>