1. Course Desc<x>ription
<br>This class will introduce the theory, practice, and application of single particle 
<br>cryo-EM. This course will discuss practical and conceptual approaches to structure 
<br>determination using these techniques, as well as covering a wide range of state-
<br>of-the-art applications of cryo-EM in the biological sciences. 
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<br>2. Text Books
<br>N/A
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<br>3. References
<br>Selected papers from high profile journals
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<br>4. Teaching Method
<br>All students are required to read all assigned papers and participate in classroom 
<br>discussion.
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<br>5. Syllabus
<br>This course encourages students to discuss publications from peer-reviewed 
<br>journals and presents their own experimental progress. Through oral presentations 
<br>and peer discussion, students will explore different aspects of the cryo-EM field. 
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<br>Week 1. Historical perspective on structural biology methods
<br>Week 2. Unique capabilities of cryo-EM: Zika virus and SARS-Cov2 virus
<br>Week 3. Unique capabilities of cryo-EM: actin and microtubules
<br>Week 4. Unique capabilities of cryo-EM: TRPV channel
<br>Week 5. Unique capabilities of cryo-EM: ribosome
<br>Week 6. Unique capabilities of cryo-EM: spliceosome
<br>Week 7. Unique capabilities of cryo-EM: Tau filaments
<br>Week 8. Unique capabilities of cryo-EM: Transc<x>ription complex
<br>Week 9. Unique capabilities of cryo-EM: Telomerase and telomere
<br>Week 10. Current limits of cryo-EM and its true potential
<br>Week 11. Tomography
<br>Week 12. 2-D crystallography
<br>Week 13 and afterwards. Experimental reports from participants.
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<br>6. Evaluation
<br>In class discussion: 50%
<br>Oral presentation: 50%
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