課程說明(Course Desc<x>ription):
<br>The novel topics is focused on organelle dynamics and is ba<x>sed on the recent 
<br>advance of microscopy. The course will go further to discuss the interactions 
<br>between organelles. and the rate of flux and exchange of intracellular content 
<br>(such as me<x>tals, lipids and proteins). Through various interactions, organelle 
<br>dynamics and contacts have proven to be essential for cell survival, growth and 
<br>death. The disrupted balance of organelle dynamics had been implicated in a 
<br>variety of diseases, such as neurodegenerative diseases, diabetes, cardiovascular 
<br>disease, and cancer. This course aims to introduce the concept of organelle 
<br>dynamics to facilitate better understanding. The goal is to provide knowledge 
<br>background of the molecular mechanisms underlying organelle dynamics in both 
<br>normal and pathophysiological conditions. 
<br>
<br>指定用書(Text Books):
<br>N/A
<br>
<br>參考書籍(References):
<br>The Biogenesis of Cellular Organelles.  Landes Biosciences, 2005, ISBN: 0-306-
<br>47990-7
<br>Related papers in the latest journals such as Nature, Science, Cell and Journal of 
<br>Cell Biology. 
<br>
<br>教學方式(Teaching Method)
<br>English lectures with problem ba<x>sed (PBL) group discussions
<br>
<br>教學進度(Syllabus):
<br>Week 1: Introduction
<br>Week 2: Organelle biogenesis
<br>Week 3: Endoplasmic reticulum
<br>Week 4: The Golgi apparatus
<br>Week 5: Lysosome and peroxisome
<br>Week 6: Mitochondria
<br>Week 7: The dynamics of mitochondria
<br>Week 8: The dynamics of peroxisome
<br>Week 9: Mid-term
<br>Week 10: ER-mitochondria contacts 
<br>Week 11: ER-Golgi membrane trafficking
<br>Week 12: Calcium signaling and organelles
<br>Week 13: Protein sorting
<br>Week 14: Protein transport and organelle dynamics
<br>Week 15: Nucleogenesis 
<br>Week 16: Organelle dynamics and me<x>tabolism
<br>Week 17: Organelle dynamics and pathogenesis
<br>Week 18: Final Exam
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<br>成績考核(Evaluation)
<br>40 % - Mid-term Exam
<br>40 % - Final Exam
<br>15 % - Discussion in the classes
<br>5 % - Attendance
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<br>可連結之網頁位址 相關網頁(Personal Website)
<br>E-learning platform: eeclass of National Tsing Hua University
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