一、課程說明(Course Desc<x>ription)
<br>This course is designed for graduate students. The completion of a Human Genome 
<br>Project has significant implications for molecular biology, medical epidemiology 
<br>and environmental toxicology. New molecular techniques are ba<x>sed on a better 
<br>understanding of genes and their actions rapidly proliferate into laboratories; 
<br>thus, the students need to have a broad knowledge of me<x>tabolism, mechanisms and 
<br>effects of toxicants and epidemiology in human population. This course spans 
<br>from basics of biochemical processes that are affected by toxicants to molecular 
<br>mechanisms of action, and to current experimental approaches in epidemiology and 
<br>toxicology.
<br>
<br>
<br>二、指定用書(Text Books)
<br>1. Curtis D. Klaassen and John B. Watkins III. Casarett & Doull's Essentials of 
<br>Toxicology. 
<br>2. Leon Gordis. Epidemiology: with STUDENT CONSULT Online Access.
<br>
<br>
<br>
<br>三、參考書籍(References)
<br>1. John Timbrell. The poison paradox – Chemicals as friends and foes. Oxford 
<br>University Press.
<br>2. Chris Kent. Basics of toxicology. Wiley-Liss, A John Wiley & Sons, Inc., 
<br>Publication.
<br>3. Gary D. Friedman. Primer of Epidemiology. McGraw-Hill.
<br>
<br>
<br>四、教學方式(Teaching Method)
<br>Lecture
<br>Presentation
<br>
<br>
<br> 五、教學進度(Syllabus)
<br> 1. Introduction 
<br> 2. Epidemiology and Toxicology
<br> 3. me<x>tabolism: absorption, distribution and excretion of Toxicants   
<br> 4. Biotransformation of xenobiotics
<br> 5. Modification factors of toxic effect
<br> 6. Molecular biology of toxicity: reactive oxygen species, heavy me<x>tals, 
<br>pesticides, radiation, pathogens, carcinogen, etc.
<br> 7. Toxicology techniques
<br> 8. Desc<x>ription epidemiology
<br> 9. Analytic epidemiology
<br>10. Molecular epidemiology
<br>11. Experimental study design in practice (Statistics): Excel, SPSS, SigmaPlot
<br>12. Toxicogenomics: DNA damage and repair, genetic polymorphisms (ecotoxicology)
<br>
<br>
<br>六、成績考核(Evaluation)
<br>Midterm (open book): 60% 
<br>Presentation & Discussion: 40%
<br>