Course： Structural Biology, Bioinformatics and Drug Target of 
<br>Infectious and Noncommunicable Diseases
<br>疾病結構生物資訊學
<br>Lecturer：Wen-guey WU 吳文桂 (LS Build II)
<br>Time: Thursday afternoon R6R7 (14:20-16:10)
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<br>Recent progress in structural and computational biology has allowed us to understand the structural basis at the atomic level on how drug target membrane receptors and carrier proteins to perturb the cell signaling process. The course is designed to provide students with an in-depth overview of the concepts and applications of structural biology and bioinformatics to diseases. Students will learn how to use frontier biotechnologies to investigate infectious and non-communicable diseases and facilitate potential student’s choice for the future research projects. The course will cover three major sections: (1) Introduction to Infectious and noncommunicable diseases (2) Structural biology and bioinformatic basis for drug target (3) Application of structural biology and bioinformatics to diseases. The course will be discussed in English after assigned reading by students. Since the course is designed to help students getting into
<br>research topics, students who try to elect this class should have a background in Biochemistry and Cell Biology.
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<br>Section 1: Introduction to Infectious and noncommunicable diseases
<br>1st Week   Feb 16 WHO and Neglected tropical diseases
<br>2nd Week  Feb 23 Research tools for infectious and non-communcable diseases
<br>3rd Week  Mar 02 Influenza, Diphtheria, Measles, Zika virus in Asia
<br>4th Week  Mar 09 Antimicrobial resistance
<br>5th Week  Mar 16 Innate and adaptive immune response
<br>6th Week  Mar 23 Hijacking cell signaling pathway
<br>7th Week  Apr 13 09 Midterm I (20%)
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<br>Section 2: Structural biology and bioinformatic basis for drug target
<br>8th Week   Apr 20 Proteins, lipids, carbohydrates and DNA/RNA as targets
<br>9th Week   Apr 27  G protein couple receptors 
<br>10th Week May 04 Receptor Tyrosine Kinase dimerization
<br>11th Week May 11 Ion channels gating and specificity
<br>12th Week May 18 Carrier proteins
<br>13th Week May 25 Midterm II
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<br>Section 3: Application of structural biology and bioinformatics to diseases
<br>14th Week Jun 01 Use genomics to understand infectious disease spread
<br>15th Week Jun 08 Vaccines and microbiota
<br>16th Week Jun11 Final Examination (30%)
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<br>1. The assigned reading will be posted at NTHU iMLS website for registered students.
<br>2. Grade: (I)Midterm I & II (40%)、(II) Oral (30%)、(III)Final (30%)
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