課程說明
<br>In this course, we will first describe the basic knowledge on RNA, followed by 
<br>various experimental approaches used for characterization of RNAs and RNA-protein 
<br>complexes. We further elaborate recent advent of a series of effective RNA-
<br>ba<x>sed 
<br>therapeutics against diseases that cannot be treated with other conventional drug 
<br>groups. In the final part of this course, each student will choose an application 
<br>of RNA ba<x>sed technologies, give an oral presentation in the class and lead the 
<br>group discussion.
<br>
<br>
<br>參考書籍
<br>Fundamentals of RNA structure and function
<br>Grover, Neena, editor.; 2022 Springer Nature eBook
<br>
<br>Various scientific papers from journals (nature methods, etc.)
<br>
<br>RNA therapeutics : the evolving landscape of RNA therapeutics
<br>Giangrande, Paloma H., Franciscis, Vittorio de, Rossi, John J.; 2022 Academic 
<br>Press, 
<br>
<br>
<br>教學進度
<br>Week 1. Composition and architecture of RNA
<br>Week 2. Catalytic RNA: Ribozyme and spliceosome
<br>Week 3. RNA modifications
<br>Week 4. RNA-protein interaction
<br>Week 5. RNA Methodologies I
<br>Week 6. RNA Methodologies II
<br>Week 7. Different types of RNAs and their functions
<br>Week 8. Midterm exam
<br>Week 9. mRNA Therapeutics and Functional Implications
<br>Week 10. ASO Therapeutics and Functional Implications
<br>Week 11. siRNA Therapeutics and Functional Implications
<br>Week 12. miRNA Therapeutics and Functional Implications
<br>Week 13. Aptamer Therapeutics and Functional Implications
<br>Week 14. Drug delivery systems for RNA therapeutics 
<br>Week 15. Oral presentation: Case study of RNA therapy I
<br>Week 16. Oral presentation: Case study of RNA therapy II
<br>Week 17. Oral presentation: Case study of RNA therapy III
<br>Week 18. Oral presentation: Case study of RNA therapy IV
<br>
<br>成績考核
<br>100% Oral presentation and discussion
<br>