一、	課程說明
<br>The proposed lecture focuses on the regulation of cell cycle progression, 
<br>especially mitotic progression control and its possible implication in the 
<br>development of chromosome instability and cancer. 
<br>二、	指定用書
<br>None	
<br>三、	參考書籍
<br>Updated references	
<br>四、	教學方式
<br>Teaching Method	Give lectures and discuss with students
<br>五、	教學進度
<br>Syllabus	See below for information
<br>六、	成績考核
<br>Evaluation	Attendance, midterm exam and final exam
<br>
<br>
<br>大綱
<br>I.	Cell cycle overview
<br>Just to give a comprehensive understanding the events of the eukaryotic cell cycle 
<br>and their basic control system
<br>II.	Model organisms for the study in cell cycle control
<br>To introduce several model organisms which are used to study the cell cycle 
<br>control. Explain and describe the unique features for each organism. Yeast (both 
<br>budding and fission), Xenopus laevis, Drosophila melanogaster and mammalian 
<br>systems will be discussed.
<br>III.	Basic cell cycle control system
<br>Introduction of major components of basic cell cycle control machinery including 
<br>cyclin dependent kinases, cyclin, anaphase promoting complex (APC) and their 
<br>regulation. 
<br>IV.	DNA replication/Chromosome duplication
<br>A brief introduction of chromosome duplication in G1/S phase and its regulation. 
<br>V.	Entry into mitosis
<br>Discuss about the events that control the mitotic entry. Explain what do cell do 
<br>to get an access into mitosis. 
<br>VI.	The mitotic spindle assembly
<br>Introduce the process of mitotic spindle formation, the role of chromosome 
<br>structure, spindle pole body separation, cell geometry for bi-orientation, and the 
<br>kinetochore attachments. 
<br>VII.	The spindle assembly checkpoint – the activation and maintenance
<br>Describe how does SAC monitor both the kinetochore-microtubule attachment and 
<br>tension in-between sister chromatids and how the “wait-anaphase” signal is 
<br>maintained or activated before anaphase onset.
<br>VIII. The spindle assembly checkpoint – the satisfaction and silencing
<br>Discuss the subsequent event when SAC is satisfied. The control for anaphase onset 
<br>by the activation of separase, cdc14, APC/C and inactivation of cyclin B/Cdk1.
<br>IX. Cytokinesis
<br>Describe how does a cell execute division of cytoplamic components and perform 
<br>abscission after chromosome separation.
<br>X. On the road to cancer: mitotic adaptation, slippage, catastrophe and aneuploidy
<br>Discuss what happens when cells can not satisfy the SAC, the outcome of mitotic 
<br>adaptation, slippage, catastrophe and aneuploidy caused by the failure in mitosis.
<br>