課程名稱:分子生醫基礎
英文課名:Introduction to Molecular biomedicine
課程編號:BMES 520100; 學 分 數:3
地點時間:醫環系101R / Wednesday Morning 2nd, 3rd, 4th class (9:20-12:00)

授課教師:莊淳宇 / Room 217 / ext 34229 / cychuang@mx.nthu.edu.tw

講 義: eeclass (https://eeclass.nthu.edu.tw/)

Purpose
This course consists of lecture topics, concept of lab technique and periodic
examinations for basic molecular biology and medicine. The students are expected
to develop a comprehensive understanding of molecular biology and to be able to
critically select necessary techniques in their own research. This course is
designed for the graduate and advanced undergraduate students interested in
molecular biomedicine even though without biology background.

Performance: Lecture, Presentation, Examination

Schedule
Lecture Topic [Lab Hint]
Introduction
Ch. 3, 4: DNA Nature [Ch. 21: Purification of nucleic acid]
Ch. 5: DNA Replication [Ch. 21: Detection of nucleic acid]
Ch. 6: Gene Transcription
Ch. 13: Mutations [Ch. 23: PCR]
Ch. 14: Repair
Ch. 22, 16: Recombinant DNA [Ch. 22: Restriction Endonucleases]
Ch. 9: Transcription in prokaryotes
Ch. 10: Transcription in eukaryotes [Ch. 25: Analysis of gene expression]
Ch. 11: Regulation of RNA level
Ch. 12: RNA processing
Ch. 7, 8: Protein synthesis (Translation)
Ch. 24, 26: Genomics, Proteomics
Presentation: Group Oral


Text Book
David P. Clark. Molecular Biology, Academic Cell (ISBN-10:
0123785944).


Reference
1. James D. Watson. Molecular Biology of the Gene. Pearson.
2. Robert F Weaver. Molecular Biology. McGraw-Hill Education.
3.Roger L Miesfeld. Applied Molecular Genetics. Wiley-Liss, A John Wiley & Sons,
Inc.,
Publication.
4. Dennis W Ross. Introduction to Molecular Medicine. Spring.


Presentation: 5 groups

Grades: Midterm exam: 35%; Final exam: 35%, Presentation: 30%

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