一. 課程目標(Course ob<x>jective)
<br>1.	 Develop basic concepts of Cancer Biology
<br>2.	 Learn to integrate and apply various concepts to Cancer Therapy
<br>
<br>二. 課程說明(Course Desc<x>ription) 
<br>The impact of cancer on human health is immense, driving force to accelerate 
<br>research effort 
<br>on 
<br>understanding of the basic biology of cancer, leading to more effective treatment 
<br>strategies 
<br>and more 
<br>sensitive and accurate diagnosis tools. This course will provide a comprehensive 
<br>coverage of 
<br>virtually all 
<br>areas of cancer research, emphasizing the cellular and molecular basis of cancer 
<br>and 
<br>development of 
<br>therapeutic strategy. The first half of the course will discuss the genetic and 
<br>molecular basis 
<br>of cancer. We 
<br>will explore the regulation of cell cycle, cell death, cell signaling and 
<br>me<x>tabolism in cancer. 
<br>The second 
<br>half 
<br>of the course will focus on the tumor microenvironment and therapy strategy. We 
<br>will shift our 
<br>attention to 
<br>the surrounding stromal cells instead of cancer cells. Every lecture will include 
<br>a discussion of 
<br>the rational 
<br>treatment of cancer. In the final section, we will explore the development of 
<br>novel therapeutic 
<br>strategies for 
<br>cancer. 
<br>
<br>
<br>二、指定用書或參考書籍(Text Books and References) 
<br>The Biology of Cancer, 2nd edition, 2013; Garland Science; Robert A. Weinberg.
<br>
<br>三、成績考核(Evaluation) 
<br>Exam (mid-term and final) 60% 
<br>Writing assignment 20%
<br>Group performance 10% 
<br>Attendance 10% 
<br>
<br>四、教學進度(Syllabus)
<br>
<br>1. Introduction of Cancer Biology and Therapy	
<br>2. Cell cycle and Cancer 	
<br>3. Senescence and Cancer	
<br>4. Cell death and Cancer	
<br>5. Apoptosis, Autophagy and Cancer
<br>6. Cell signaling and Cancer	
<br>7. Midterm
<br>8. me<x>tabolism and Cancer	
<br>9. Angiogenesis and Cancer
<br>10. me<x>tastasis I	
<br>11. me<x>tastasis II
<br>13. Cancer immunity
<br>14. Cancer Diagnosis and Treatment
<br>15. Cancer Nanotech
<br>16. Final Exam
<br>
<br>五. 講師 (Instructor)
<br>
<br>Dr. Yunching Chen
<br>http://mx.nthu.edu.tw/~yunching/drug_targeting_lab/PI.html
<br>
<br>課程內容 ：
<br>涵蓋癌症生物學機制, 由細胞分裂, 複製, 凋亡談起, 
<br>延伸至癌細胞代謝和血管新生, 癌轉移和免疫脫逃……等. 
<br>每一單元根據其相關機制探討和設計相應的治療策略, 
<br>在治療端的探討包含小分子藥物, 大分子蛋白藥, 基因治療, 
<br>免疫治療, 利用藥物輸送系統克服癌症治療上的困難……等. 
<br>
<br>授課方式：
<br>本課程為研究所課程, 上課方式合併一般講課 (75%) 和課堂小組討論 (25%), 
<br>每一單元皆設計3~4個開放性討論問題, 
<br>培養同學獨立思考和研究能力, 教師亦參與討論並給予回饋. 
<br>
<br>評分方式：
<br>包含一次期末小組口頭報告以及兩次筆試.
<br>筆試內容80%來自公開題目
<br>
<br>