一、課程說明
<br>本門課程旨在(1)回顧四大生物分子及基礎無機化學、(2)金屬酵素功能以及作用機制介紹、(3)臨床
<br>使用金屬生物醫藥介紹、(4)金屬生物醫藥及生醫材料的設計與開發。於學期末則安排由學生挑選相
<br>關主題，進行口頭報告。
<br>
<br>This class aims to (1) review four kinds of biomolecules and basic inorganic 
<br>chemistry, (2) function and reaction mechanism of me<x>talloenzymes, (3) 
<br>introduction of FDA-approved me<x>tallopharmaceutics, (4) design and development 
<br>of 
<br>me<x>tal-ba<x>sed biomedicine and biomaterials. In the end of the semester, 
<br>students 
<br>have to choose a topic and give an oral presentation relevant to the me<x>tal 
<br>pharmaceutical chemistry & biomaterial.
<br>
<br>二、指定用書
<br>上課講義
<br>
<br>三、參考書籍
<br>1. Principles of Bioinorganic Chemistry.
<br>Stephen J. Lippard, Jeremy M. Berg.
<br>ISBN: 0935702725
<br>2. Biological Inorganic Chemistry
<br>Ivano Bertini, Harry B. Gray, Edward I. Stiefel, Joan S. Valentine
<br>ISBN:1891389432
<br>
<br>四、教學方式
<br>(1) 講授 Lecture
<br>(2) 口頭報告 Oral presentation
<br>(3) 課堂討論
<br>
<br>五、教學進度
<br>Week 1 
<br>課程簡介 Introduction
<br>Week 2-3 
<br>基礎生物分子回顧與介紹 Review of biomolecules
<br>Week 4 
<br>基礎化學與無機化學回顧與介紹 Review basic and inorganic chemistry
<br>Week 5-8 
<br>含鐵、銅、鋅金屬酵素的發現、結構、功能 
<br>Discovery, structure, and function of Fe-containing me<x>talloenzyme 
<br>Week 9-10 
<br>具生醫應用的金屬錯合物：cis-platin抗癌藥物
<br>me<x>tal complexes for biomedical application: anti-cancer drug cis-platin
<br>Week 11-12 
<br>具生醫應用的金屬錯合物：Tc/Gd/Mn/Fe3O4生物影像顯影劑
<br>me<x>tal complexes for biomedical application: contrast reagent for bioimaging
<br>Week 13-15 
<br>具生醫應用的金屬錯合物：一氧化氮控制遞送及生醫應用
<br>me<x>tal complexes for biomedical application: controlled delivery of nitric 
<br>oxide 
<br>and biomedical application
<br>Week 16-18 
<br>期末考及期末口頭報告 Final exam and oral presentation
<br>
<br>六、成績考核
<br>期末考 Final exam (50%)
<br>期末報告 oral presentation (40%)
<br>平時成績 Attendance (10%)
<br>
<br>
<br>