一、課程說明(Course Description)
免疫系統是一專一且高度多樣化之個體防禦系統,在這防禦系統中,各類特定功能的細胞與分子密切
合作形成一動態的網絡,藉以清除致病性微生物與癌細胞。然而免疫系統的失調以及微生物與癌細胞

反制亦造成感染症、癌症、及自體免疫疾病的惡化,我們該如何設計有效的免疫療法及疫苗? 近年
來,由於免疫學研究有多項突破性的進展,使得這門科學漸趨成熟,已成為二十一世紀之顯學。無庸
至疑地,免疫學是一不可或缺的生命科學課程。

本課程歡迎對免疫學有興趣的大學部學生及研究生修習。亦歡迎非生科系院同學選修。課程內容包括
探討基本的免疫學現象及機制,簡言之,即是分子辨識(molecular recognition) 與反應
(response),以及免疫學在生物醫學及產業的應用,如免疫療法(immunotherapy)、單株抗體、疫
苗設計、生物感應器(biosensors)等。

二、指定用書(Text Books)
Parham's The Immune System, 5th Edition, 2021; Garland Science; ed: Peter Parham

三、參考書籍(References)

Kuby Immunology, 9th Edition, 2019; W. H. Freeman and Company; eds: Thomas
Kindt, Richard Goldsby, Barbara Osborne.

Cellular and Molecular Immunology, 7th Edition, 2012; Elsevier Inc., eds: Abul K.
Abbas, Andrew H. Lichtman, Shiv Pillai.

Scientific journal articles and reviews

Janeway's Immunobiology, 9th Edition, 2016; Garland Science; ed: Kenneth Murphy

四、教學方式(Teaching Method)
Lectures/ 新知介紹

五、教學進度(Syllabus)
Week Data
1 9/11 Overview of immune system
2 9/18 The induced responses of innate immunity
3 9/25 Antibody Structure and the Generation of B-Cell Diversity
4 10/2 Antigen Recognition by T Lymphocytes
5 10/10 國慶日
6 10/16 First-Exam
7 10/23 The Development of B Lymphocytes
8 10/30 The Development of T Lymphocytes
9 11/6 T Cell-Mediated Immunity
10 11/13 Immunity Mediated by B Cells and Antibodies
11 11/20 Second-Exam
12 11/27 Immunological Memory and Vaccination
13 12/4 Failures of the Body’s Defenses
14 12/11 Allery, hypersensivities, and chronic inflammation
15 12/18 Tolerance, autoimmunity, transplantation, cancer and the immune
system
16 12/25 Final exam

六、成績考核(Evaluation)
暫定:
Exam 70% (20% / 20% / 30%)
Homework 15%
Quiz 15%