微生物毒性因子
Microbial Virulence Factors

教師:王雯靜時間:M3
地點:生科二館107室

Brief Description
This course covers the concepts of how bacteria interact with their host and
examines the factors that allow microorganisms to colonize and survive in the
host. Additionally, it will explore how bacteria can use the host to their
advantage. The course will also look at experimental techniques used to study the
relationship between bacteria and their hosts, including the use of cell lines
and animal models to investigate microbial pathogenicity. Finally, we will
discuss the molecular pathogenesis of selected pathogens.

Introduction
The search for Infections Causes of Human Cancers
Helicobacter pylori and gastrointestinal disease
Bacterial protein toxins
Cholesterol-α-glucosyltransferase
AB-type toxins and pore-forming toxins
Clostridium tetani & tetanus toxin
Clostridium botulinum & botulinum toxin
Escherichia coli & heat-labile toxin, verotoxin
Shigella dysenteria & shiga toxin
Vibrio cholerae & cholera toxin,
Bacillus anthracis & Anthrax toxin
Bordetella pertussis & Pertussis toxin
Corynebacterium diphtheriae& diphtheria toxin
Campylobacter jejuni & cytolethal distending toxin
Inflammasome Activation by Microbial Infection
Epigenetics and Cancer
Microbiome
Practical Research in Microbial Virulence Factors
Final Report and examination

AI Usage Rules: Conditionally open; please specify how generative AI will be used
in course output.

參考書本:
1. Alouf, J. E. and Freer, J. H. (1999). Bacterial protein toxins. Academic
Press.
2. Evans, A. S. and Brachman, P. S. (2013). Bacterial Infections of Humans.
Epidemiology and Control. Plenum Medical. Edition 3