微生物毒性因子
<br>Microbial Virulence Factors
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<br>教師：王雯靜時間：M3
<br>地點：生科二館107室
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<br>Brief Desc<x>ription
<br>This course covers the concepts of how bacteria interact with their host and 
<br>examines the factors that allow microorganisms to colonize and survive in the 
<br>host. Additionally, it will explore how bacteria can use the host to their 
<br>advantage. The course will also look at experimental techniques used to study the 
<br>relationship between bacteria and their hosts, including the use of cell lines 
<br>and animal models to investigate microbial pathogenicity. Finally, we will 
<br>discuss the molecular pathogenesis of selected pathogens.
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<br>Introduction
<br>The search for Infections Causes of Human Cancers
<br>Helicobacter pylori and gastrointestinal disease
<br>Bacterial protein toxins
<br>Cholesterol-α-glucosyltransferase
<br>AB-type toxins and pore-forming toxins
<br>Clostridium tetani & tetanus toxin
<br>Clostridium botulinum & botulinum toxin
<br>Escherichia coli & heat-labile toxin, verotoxin
<br>Shigella dysenteria & shiga toxin
<br>Vibrio cholerae & cholera toxin, 
<br>Bacillus anthracis & Anthrax toxin
<br>Bordetella pertussis & Pertussis toxin
<br>Corynebacterium diphtheriae& diphtheria toxin
<br>Campylobacter jejuni & cytolethal distending toxin
<br>Inflammasome Activation by Microbial Infection
<br>Epigenetics and Cancer
<br>Microbiome
<br>Practical Research in Microbial Virulence Factors
<br>Final Report and examination
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<br>AI Usage Rules: Conditionally open; please specify how generative AI will be used 
<br>in course output.
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<br>參考書本:
<br>1. Alouf, J. E. and Freer, J. H. (1999). Bacterial protein toxins. Academic 
<br>Press.
<br>2. Evans, A. S. and Brachman, P. S. (2013). Bacterial Infections of Humans. 
<br>Epidemiology and Control. Plenum Medical. Edition 3
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