中文名稱: 進階微流體系統
英文名稱：Advanced Microfluidic Systems
授課老師：李國賓
學 分 數：3學分
擬開課年級:碩博
This course is designed for graduate students who have taken fundamental courses
in Microfluidics (such as PME 5170 Thermo-fluidics in Bio-MEMS). It will cover
advanced topics in microfluidics, including critical microfluidic devices and
integrated microfluidic systems. Their biomedical applications for DNA, RNA,
proteins, and cells will be extensively investigated.
課程大綱:
1. Introduction to microfluidics
2. Review of microfabrication technologies for microfluidics- silicon-
based and non-silicon-based techniques (reading assignment)
3. Case study on micro fabrication of simple fluidic devices---micro
channel, cavity, diaphragm etc.
4. Micro flow sensors (reading assignment)
(a) Temperature sensors
(b) Pressure sensors
(c) Shear stress sensors
(d) Flow velocity sensors
5. Microfluidic devices
(a) Micro pumps
(b) Micro valves
(c) Micro mixers
(d) Micro nozzles
(e) Micro injectors
(f) Micro flow switches
(g) Micro bio-reactors
(h) Micro separators (micro capillary electrophoresis and micro-filters)
6. Microfluidic systems
(a) flow cytometer
(b) protein chips
(c) DNA chips
(d) cell chips
7. Special topics for microfluidic systems

References:
1. “Fundamental and applications of microfluidics” by Nam-Trung Nguyen and
Steven T. Wereley, 2002
2. “Microfluidic Technology and Applications (Microtechnologies and
Microsystems Series) “ by Michael Koch, et al., 2000.
3. "Microsensor - Principles and Applications", by J. W. Gardner, Wiley,
1996.
4. " Semiconductor Sensors", by S. M. Sze, John Wiley & Sons, Inc. , 1994
5. " Micromechanics and MEMS-classic and seminal papers to 1990", edited by
W. S. Trimmer, IEEE press, 1996.
6. "Fundamental of microfabrication", by Marc Madou, CRC press, New York,
1997.
7. "Micromachined Transducers- Sourcebook", by G. T. A. Kovacs, WCB/McGraw,
1998.

Grading policy:
Homework 30 %
Midterm 40 %
Final project & final presentation 30 %

** Collaboration is highly encouraged in this course. You have to form a team
with 2-3 partners to finish your final project.

Office hours:
Friday 16:00 pm –17:00 pm
Office: Rm. 608, Department of Power Mechanical Engineering, NTHU
Tel. No.: ext 33765
E-mail: gwobin@pme.nthu.edu.tw


Important deadlines:
1. First draft of proposal for your final paper: 5th week.
2. Midterm exam: 10th ~ 11th week
3. Final presentation: 17th week.
4. Final paper: 18th week.

Teaching Assistant: to be announced.

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